Results 41 to 50 of about 2,446,572 (290)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Re-run, Repeat, Reproduce, Reuse, Replicate: Transforming Code into Scientific Contributions
Frontiers in Neuroinformatics, 2018 Scientific code is different from production software. Scientific code, by producing results that are then analyzed and interpreted, participates in the elaboration of scientific conclusions.
Fabien C. Y. Benureau +5 more
doaj +1 more source
Quantum Mechanics with Trajectories: Quantum Trajectories and Adaptive Grids [PDF]
, 2003 Although the foundations of the hydrodynamical formulation of quantum mechanics were laid over 50 years ago, it has only been within the past few years that viable computational implementations have been developed.
Bittner, Eric R., Wyatt, Robert E.
core +2 more sources
BOSS-LDG: A Novel Computational Framework that Brings Together Blue Waters, Open Science Grid, Shifter and the LIGO Data Grid to Accelerate Gravitational Wave Discovery [PDF]
, 2017 We present a novel computational framework that connects Blue Waters, the NSF-supported, leadership-class supercomputer operated by NCSA, to the Laser Interferometer Gravitational-Wave Observatory (LIGO) Data Grid via Open Science Grid technology.
Anderson, Stuart +11 more
core +2 more sources
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Mathematical modeling based on ordinary differential equations: A promising approach to vaccinology
Human Vaccines & Immunotherapeutics, 2017 New contributions that aim to accelerate the development or to improve the efficacy and safety of vaccines arise from many different areas of research and technology.
Carla Rezende Barbosa Bonin +3 more
doaj +1 more source
Using Graphing Calculators to Integrate Mathematics and Science [PDF]
, 1997 The computational, graphing, statistical and programming capabilities of today’s graphing calculators make it possible for teachers and students to explore aspects of functions and investigate real-world situations in ways that were previously ...
Garofalo, J., Pullano, F.
core +1 more source
The science in computer science
Communications of the ACM, 2013 Computer science is in a period of renaissance as it rediscovers its science roots.
openaire +2 more sources