Results 71 to 80 of about 2,446,572 (290)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Computational reproducibility in computational social science

EPJ Data Science
Open science practices have been widely discussed and have been implemented with varying success in different disciplines. We argue that computational-x disciplines such as computational social science, are also susceptible to the symptoms of the crises,
David Schoch, Chung-hong Chan, Claudia Wagner, Arnim Bleier   +3 more
doaj   +1 more source

Applying computational complexity to the emergence of classicality [PDF]

, 2013
Can the computational complexity theory of computer science and mathematics say something new about unresolved problems in quantum physics? Particularly, can the P versus NP question in the computational complexity theory be a factor in the elucidation ...
Bolotin, Arkady
core  

Educating and Training Accelerator Scientists and Technologists for Tomorrow

, 2012
Accelerator science and technology is inherently an integrative discipline that combines aspects of physics, computational science, electrical and mechanical engineering.
Barletta, William A., Chattopadhyay, Swapan, Seryi, Andrei   +2 more
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Long time dynamics and coherent states in nonlinear wave equations

, 2016
We discuss recent progress in finding all coherent states supported by nonlinear wave equations, their stability and the long time behavior of nearby solutions.Comment: bases on the authors presentation at 2015 AMMCS-CAIMS Congress, to appear in Fields
A. Floer, A. Soffer, A. Soffer, A. Soffer, C.A. Pillet, D. Bambusi, E. Kirr, E. Kirr, E. Kirr, E. Kirr, E.W. Kirr, G. Zhou, H. Berestycki, H. Jeanjean, H. Jeanjean, H.A. Rose, I. M. Sigal, J.L. Marzuola, L. Nirenberg, M. Grillakis, M. Grillakis, M. Grillakis, M.I. Weinstein, M.I. Weinstein, P. H. Rabinowitz, P.-L. Lions, P.-L. Lions, P.G. Kevrekidis, R. A. Adams, R. K. Jackson, S. Cuccagna, S. Cuccagna, T. Cazenave, T. Mizumachi, T. Mizumachi, T.-P. Tsai, T.-P. Tsai, T.-P. Tsai, V. S. Buslaev, V. S. Buslaev, W.H. Aschbacher, Y. Guo, Y.-G. Oh   +42 more
core   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Protein Design is NP-hard [PDF]

, 2002
Biologists working in the area of computational protein design have never doubted the seriousness of the algorithmic challenges that face them in attempting in silico sequence selection. It turns out that in the language of the computer science community,
Pierce, Niles A., Winfree, Erik
core  

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source