Results 81 to 90 of about 8,550,305 (373)
Computational Social Science and Sociology.
The Annual review of sociology, 2020 The integration of social science with computer science and engineering fields has produced a new area of study: computational social science. This field applies computational methods to novel sources of digital data such as social media, administrative ...
Achim Edelmann +3 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Computational thinking in life science education. [PDF]
PLoS Computational Biology, 2014 We join the increasing call to take computational education of life science students a step further, beyond teaching mere programming and employing existing software tools.
Amir Rubinstein, Benny Chor
doaj +1 more source
Protein Design is NP-hard [PDF]
, 2002 Biologists working in the area of computational protein design have never doubted the seriousness of the algorithmic challenges that face them in attempting in silico sequence selection. It turns out that in the language of the computer science community,
Pierce, Niles A., Winfree, Erik
core
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Special Issue “Computational Social Science”
Information, 2019 The last centuries have seen a great surge in our understanding and control of “simple” physical, chemical, and biological processes through data analysis and the mathematical modeling of their underlying dynamics [...]
Gerardo Iñiguez +2 more
doaj +1 more source
Applying computational complexity to the emergence of classicality [PDF]
, 2013 Can the computational complexity theory of computer science and mathematics say something new about unresolved problems in quantum physics? Particularly, can the P versus NP question in the computational complexity theory be a factor in the elucidation ...
Bolotin, Arkady
core
The skewness of computer science [PDF]
Information Processing & Management, 2011 I applied the goodness-of-fit methodology proposed in: A. Clauset, C. R. Shalizi, M. E. J. Newman. Power-law distributions in empirical data. SIAM Review 51, 661-703 (2009)
openaire +2 more sources