Results 81 to 90 of about 27,547 (261)

Transcriptional regulation of neuropeptide receptors underlies context‐dependent adaptation in Drosophila melanogaster

open access: yesFEBS Open Bio, EarlyView.
Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu   +6 more
wiley   +1 more source

Critical computational social science

open access: yesEPJ Data Science
In her 2021 IC2S2 keynote talk, “Critical Data Theory,” Margaret Hu builds off Critical Race Theory, privacy law, and big data surveillance to grapple with questions at the intersection of big data and legal jurisprudence.
Sarah Shugars
doaj   +1 more source

A unified model for Duchenne muscular dystrophy gene involvement in cancer: context‐dependent tumour suppression and oncogenicity

open access: yesFEBS Open Bio, EarlyView.
We propose a context‐dependent model where the Duchenne muscular dystrophy (DMD) gene acts as a tumour suppressor in aggressive tumours and as an oncogene in less aggressive ones. We propose this model as a unified framework to explain the opposing survival associations with DMD expression and to guide experimental exploration of the dual role of DMD ...
Lee Machado   +4 more
wiley   +1 more source

Computational urban science needs to go beyond computational

open access: yesComputational Urban Science
In this paper, I advocate for a radical expansion of computational urban science to encompass a multidisciplinary, human-centered approach, addressing the inadequacies of traditional methodologies in capturing the complexities of urban life.
Xiao Huang
doaj   +1 more source

Computational Ecology: an emerging ecological science [PDF]

open access: yesComputational Ecology and Software, 2011
Computational ecology is an emerging science to integrate and synthesize computation intensive areas in ecology. It was clearly defined and described in an earlier study. Aims and scope of computational ecology are further refined in present discussion.
WenJun Zhang
doaj  

Electrical pulse stimulation reflecting the episodic nature of real‐life exercise modulates metabolic and secretory profile of primary human myotubes

open access: yesFEBS Open Bio, EarlyView.
Here, we introduced an intermittent electrical stimulation protocol mimicking the episodic nature of real‐life exercise in vitro by alternating low‐ and high‐frequency stimulation. In comparison with widely used continuous stimulation, it enhanced the rate of glucose and fatty acid oxidation, but not the myokine release.
Klára Gabrišová   +11 more
wiley   +1 more source

Computational Archival Science [PDF]

open access: yesModerna arhivistika, 2018
The digitisation of archival materials and ingest of digitally born materials in digital archives has led to the possibilities of application of the big data analytical principles in the digital archives. The author explains the 5V characteristics of big data. He proceeds to define the concept of Computational Archival Science (CAS).
openaire   +2 more sources

The impact of Hnrnpl deficiency on transcriptional patterns of developing muscle cells

open access: yesFEBS Open Bio, EarlyView.
We performed nanopore whole‐transcriptome sequencing comparing RNA from Hnrnpl‐knockdown versus control C2C12 myoblasts to investigate the contributions of Hnrnpl to muscle development. Our results indicate that Hnrnpl regulates the expression of genes involved with Notch signaling and skeletal muscle, particularly splicing patterns of specific muscle ...
Hannah R. Littel   +8 more
wiley   +1 more source

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