Results 31 to 40 of about 39,144,787 (249)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Critical computational social science

EPJ Data Science
In her 2021 IC2S2 keynote talk, “Critical Data Theory,” Margaret Hu builds off Critical Race Theory, privacy law, and big data surveillance to grapple with questions at the intersection of big data and legal jurisprudence.
Sarah Shugars
doaj   +1 more source

Editorial: Computational Social Science as the ultimate Web Intelligence [PDF]

, 2020
Computational Social Science (CSS) is the use of Web Intelligence and the tools and technology capable of monitoring, analyzing, diagnosing, and resolving day-to-day problems of society.
Velasquez-Silva, Juan Domingo, Liu, Jiming, Tao, Xiaohui, Zhong, Ning, Velásquez Silva, Juan   +4 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Perspectives of the International Conference of Computational Science 2014

, 2015
Computational Science has enabled a raft of science that was either impossible, dangerous, or extremely expensive. It is arguably one of the most multi-disciplinary research endeavors, and draws on foundational work in mathematics and computer science ...
Abramson, D., Abramson, David, Lees, Michael, Krzhizhanovskaya, V.V., Krzhizhanovskaya, V.V.; id_orcid, Krzhizhanovskaya, Valeria V., Lees, M.   +6 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Computational social science with confidence

EPJ Data Science
There is an ongoing shift in computational social science towards validating our methodologies and improving the reliability of our findings. This is tremendously exciting in that we are moving beyond exploration, towards a fuller integration with theory
Carolina E. S. Mattsson
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Towards reproducibility in online social network research [PDF]

, 2015
This work was supported by the Engineering and Physical Sciences Research Council [grant number EP/J500549/1].The challenge of conducting reproducible computational research is acknowledged across myriad disciplines from biology to computer science.
Hutton, Luke, Henderson, Tristan
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source