Results 71 to 80 of about 2,676,916 (256)

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

HIV-1 pretreatment and acquired antiretroviral drug resistance before tenofovir/ lamivudine /dolutegravir (TLD) roll-out in Mozambique

BMC Infectious Diseases
Background The World Health Organization (WHO) recommends that HIV treatment scale-up is accompanied by a robust assessment of drug resistance emergence and transmission.
Nália Ismael, Hernane Gemusse, Isabel Mahumane, Osvaldo Laurindo, Cacildo Magul, Cheryl Baxter, Eduan Wilkinson, L. Marije Hofstra, Nick Wagar, Dulce Bila, Nédio Mabunda, Juliana da Silva, Túlio de Oliveira, Elliot Raizes, Wolfgang Preiser, Pedro Manuel, Artur Ramos, Adolfo Vúbil   +17 more
doaj   +1 more source

Rethinking Computational Thinking for Public Libraries' Youth Programs: Challenges and Recommendations

Pennsylvania Libraries: Research & Practice, 2018
Computational thinking has become a popular and important concept in education throughout the nation. Public libraries, with their technology services and their role as an informal learning space, have been tagged as an ideal place for computational ...
Marissa Guidara
doaj   +1 more source

Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1

FEBS Open Bio, EarlyView.
The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn, Artur Osyczka, Marcin Sarewicz   +2 more
wiley   +1 more source

Developing Alice: A Scaffolding Agent for AI-Mediated Computational Thinking [PDF]

Recent advances in generative AI have increasingly highlighted the transformative potential of large language models (LLMs) within educational contexts.
Ali, Muhammad, Chen, Bixia, Wong, Gary Ka Wai   +2 more
core   +1 more source

Computational thinking: the developing definition

Since Jeanette Wing’s use of the term computational thinking in 2006, various discussions have arisen seeking a robust definition of the phrase. With no consensus having been found in the intervening years, there are even suggestions that a definition is
Selby, Cynthia
core   +1 more source

Exploring the Introduction of Computational Thinking in STEM Education in Australian Schools

Southeast Asian Mathematics Education Journal, 2019
This paper discusses theoretical and curricular aspects of computational thinking in curriculum and detects recent perspectives and challenges noticed in introducing computational thinking in STEM in Australian Schools.
Dorian Stoilescu
doaj   +1 more source

Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane, Valentina Giunchiglia, Michael C. B. David, Magdalena A. Kolanko, William R. Trender, Peter J. Hellyer, Harmeena Kaur, David J. Sharp, Christopher Carswell, Paresh A. Malhotra, Adam Hampshire   +10 more
wiley   +1 more source