Results 51 to 60 of about 31,386 (265)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Cosmological constant from canonical transformation in quantum cosmology

Nuclear Physics B
We explore the introduction of the cosmological constant via canonical transformations in cosmology. We consider the Wheeler-DeWitt equation for the cold dark matter (CDM) universe and we construct the Hamilton-Jacobi action for the ΛCDM model, where Λ ...
Andronikos Paliathanasis
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Sex classification of 3D skull images using deep neural networks

Scientific Reports
Determining the fundamental characteristics that define a face as "feminine" or "masculine" has long fascinated anatomists and plastic surgeons, particularly those involved in aesthetic and gender-affirming surgery.
Lake Noel, Shelby Chun Fat, Jason L. Causey, Wei Dong, Jonathan Stubblefield, Kathryn Szymanski, Jui-Hsuan Chang, Paul Zhiping Wang, Jason H. Moore, Edward Ray, Xiuzhen Huang   +10 more
doaj   +1 more source

Computational Thinking and Modeling: A Quasi-Experimental Study of Learning Transfer

Education Sciences
This quasi-experimental study investigated the impact of computational learning activities on high school students’ computational thinking (CT) and computational modeling (CM) skills.
Line Have Musaeus, Peter Musaeus
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Coding and educational robotics and their relationship with computational and creative thinking. A compressive review.

RED. Revista de Educación a Distancia, 2020
New technological tools, technology-based services and support are being introduced into our daily lives faster than ever. Among these technological advances robotic technology has increased dramatically in recent years, the same as its inclusion in ...
Raidell Avello, Jari Lavonen, Miguel Zapata-Ros   +2 more
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Transcription of Informatics Final Project Seminar Recordings via Speech-to-Text

Jurnal Pendidikan Multimedia
Bandung State Polytechnic has implemented project-oriented problem-based learning as its new educational approach. Project 6, or Final Project, is a course that communicates student learning results.
Trisna Gelar, Aprianti Nanda Sari, Djoko Cahyo Utomo Lieharyani, Fauza Naylassana, Nisrina Wafa Zakiya Hamdani   +4 more
doaj   +1 more source