Results 41 to 50 of about 31,386 (265)

Dolutegravir rollout for treatment of HIV with a focus on advanced disease and tuberculosis coinfection: findings from rural KwaZulu-Natal, South Africa (2019–2023)

AIDS Research and Therapy
Background While Dolutegravir (DTG) containing antiretroviral therapy (ART) has become the preferred regimen for people living with HIV (PLHIV), the pace and equity of its adoption, especially among subgroups with tuberculosis (TB) symptoms and advanced ...
Reuben Christopher Moyo, Larisse Bolton, Elphas Luchemo Okango, Margot Otto, Nthoesele Letoao, Peter Suwirakwenda Nyasulu, Frank Tanser   +6 more
doaj   +1 more source

Peer network approaches for improving HIV testing, prevention and care utilisation among men in sub-Saharan Africa: a scoping review

BMJ Open
Introduction Limited male engagement in HIV prevention and care is a global challenge more pronounced in sub-Saharan Africa (SSA) contributing to ongoing transmission.
Guy Harling, Frank Tanser, Paul Mee, Maxime Inghels, Khai Hoan Tram, Wilfred Ouma Otambo, Margot Otto, Ntombifuthi Blose   +7 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Controllable Many-Objective Optimization for Fairness-Aware Uplift Modeling in Recommender Systems

IEEE Access
This paper investigates the distribution of promotional offers under simultaneous budget, fairness, and treatment overlap constraints, using causal uplift modeling to estimate the incremental impact on personalized platforms and, specifically ...
Sunday O. Oladejo
doaj   +1 more source

Computational Thinking und Kontextorientierung.

Medienimpulse, 2020
Je nach Perspektive wird in der digitalen Bildung über digitale Medien, über Medienbildung, über informationstechnische Grundbildung, über Informatik, Problemlösefähigkeiten, Schlüsselkompetenzen und technische Allgemeinbildung gesprochen.
Michael Steiner, Klaus Himpsl-Gutermann
doaj   +1 more source

Computational Thinking … and Doing

Computing in Science & Engineering, 2009
This Article is brought to you for free and open access by Loyola eCommons. It has been accepted for inclusion in Computer Science: FacultyPublications & Other Works by an authorized administrator of Loyola eCommons. For more information, please contactecommons@luc.edu.This work is licensed under aCreative Commons Attribution-Noncommercial-No ...
openaire   +3 more sources

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

The “Telephone Game” effect in modern gravity research

European Physical Journal C: Particles and Fields
Triggered by some recent studies within the framework of nonmetricity gravity, I discuss how the basic information regarding the equivalence of the gravitational theories forming the “Trinity of Gravity” has been lost in parts of the literature.
Andronikos Paliathanasis
doaj   +1 more source