Results 21 to 30 of about 2,676,916 (256)
BMC GenomicsBackground Rift Valley fever virus (RVFV) is an emerging zoonotic virus of major public health and veterinary concern across Africa. Although past genomic studies have focused on outbreak response and lineage classification, the molecular mechanisms ...
Isaac Emmanuel Omara +9 more
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Understanding the Transmission Dynamics of the Chikungunya Virus in Africa
PathogensThe Chikungunya virus (CHIKV) poses a significant global public health concern, especially in Africa. Since its first isolation in Tanzania in 1953, CHIKV has caused recurrent outbreaks, challenging healthcare systems in low-resource settings.
Yajna Ramphal +9 more
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Открытое образование (Москва), 2020 Today, one of the highly discussed topics is the impact of global digitalization on the evolution of humankind. Although the widespread introduction of digital technology is considered to be effective and profitable, it requires competitive professionals,
M. U. Mukasheva, Y. V. Payevskaya
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Alignment-free viral sequence classification at scale
BMC GenomicsBackground The rapid increase in nucleotide sequence data generated by next-generation sequencing (NGS) technologies demands efficient computational tools for sequence comparison.
Daniel J. van Zyl +6 more
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
A quantum leaky integrate-and-fire spiking neuron and network
npj Quantum InformationQuantum machine learning is in a period of rapid development and discovery, however it still lacks the resources and diversity of computational models of its classical complement.
Dean Brand, Francesco Petruccione
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FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
An alternative approach for measuring computational thinking: Performance-based platform
, 2021 Educators emphasize that computational thinking is especially helpful in raising problem-solving skills, improving logical reasoning, and developing analytical thinking.
Korkmaz, Ozgen, Coban, Emre
core +1 more source