Results 81 to 90 of about 311,562 (267)

Computational Thinking Integration into Middle Grades Science Classrooms: Strategies for Meeting the Challenges [PDF]

, 2018
This paper reports findings from the efforts of a university-based research team as they worked with middle school educators within formal school structures to infuse computer science principles and computational thinking practices.
Akram, Bita, Aksit, Osman, Boyer, Kristy Elizabeth, Buffum, Philip Sheridan, Cadieux Boulden, Danielle, Lester, James, Mott, Bradford, Wiebe, Eric   +7 more
core   +1 more source

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source

Cracking the Code: Genotype–Phenotype Correlation Models in Sarcoglycanopathies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Sarcoglycanopathies are among the most severe limb‐girdle muscular dystrophies (LGMD), though milder presentations have been described. These diseases are primarily caused by missense variants, but the limited predictability of their effect on protein maturation, complex formation, and transport has hindered reliable genotype ...
Leonela Luce, Goknur Selen Kocak, José Verdú‐Díaz, Jorge Alonso‐Pérez, Kristl G. Claeys, Tanya Stojkovic, Gorka Fernández‐Eulate, Pascal Laforêt, Najoua Miladi, Filipe Di Pace, Cristiane Araujo Martins Moreno, Edmar Zanoteli, Conrad C. Weihl, Volker Straub, Ana Töpf, Jordi Díaz‐Manera, Sarcoglycan European Cohort Consortium, Adele D′Amico, Adolfo López de Munain, Alicia Alonso‐Jiménez, Ana Camacho‐Salas, Andrea Gangfuß, Andrés Nascimento, Anna Sarkozy, Anneke J. van der Kooi, Arturo Fraga‐Bau, Béla Melegh, Benedikt Schoser, Bjarne Udd, Blaz Koritnik, Carlos Ortez, Chiara Marini Bettolo, Chiara Panicucci, Claudia Weiss, Claudio Bruno, Claudio Semplicini, Cristina Dominguez‐González, Cristina Garrido, David Gómez‐Andrés, Edoardo Malfatti, Elena Pegoraro, Elke De Vos, Francina Munell, Gabriele Dekomien, Giacomo Pietro Comi, Giorgio Tasca, Isabelle Richard, Jan L. De Bleecker, Jana Haberlová, Jesper Helbo Storgaard, Johanna Palmio, John Vissing, Juan Carlos de Leon‐Hernández, Kinga Hadzsiev, Laura Costa‐Comellas, Lea Leonardis, Leroy ten Dam, Lidia González‐Quereda, Luca Bello, Luisa Politano, Manuela Santos, Marianne de Visser, Marie Rohlenová, Matteo Garibaldi, Michela Guglieri, Nicolas Deconinck, Nicoline Løkken, Omar Abdel‐Mannan, Pia Gallano, Roberto Fernández‐Torrón, Ulrike Schara‐Schmidt, Vincenzo Nigro, Vittoria Zangaro   +72 more
wiley   +1 more source

Computational thinking beyond computer science

, 2023
This chapter outlines computational thinking (CT) as a thinking framework that both crosses and goes beyond existing subjects. The chapter sets by introducing the concept of CT and linking it to the German concept of Didaktik, here highlighting both its general and subject-related aspects.
Stig Børsen Hansen, Roland Hachmann, Nina Bonderup Dohn   +2 more
openaire   +1 more source

Developing computational thinking in the classroom: a framework

, 2014
Computational thinking sits at the heart of the new statutory programme of study for Computing: “A high quality computing education equips pupils to use computational thinking and creativity to understand and change the world” (Department for Education ...
Curzon, Paul, Dorling, Mark, Ng, Thomas, Selby, Cynthia, Woollard, John   +4 more
core  

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Tracing the spatial origins and spread of SARS-CoV-2 Omicron lineages in South Africa

Nature Communications
Since November 2021, five genetically distinct SARS-CoV-2 Omicron lineages (BA.1–BA.5) are believed to have emerged in southern Africa, with four (BA.1, BA.2, BA.4, and BA.5) spreading globally and collectively dominating SARS-CoV-2 diversity.
Graeme Dor, Eduan Wilkinson, Darren P. Martin, Monika Moir, Derek Tshiabuila, Dikeledi Kekana, Buhle Ntozini, Rageema Joseph, Arash Iranzadeh, Martin M. Nyaga, Dominique Goedhals, Tongai Maponga, Jean Maritz, Oluwakemi Laguda-Akingba, Yajna Ramphal, Caitlin MacIntyre, Lucious Chabuka, Sureshnee Pillay, Jennifer Giandhari, Cheryl Baxter, Nei-yuan Hsiao, Wolfgang Preiser, Jinal N. Bhiman, Mary-Anne Davies, Marietjie Venter, Florette K. Treurnicht, Nicole Wolter, Carolyn Williamson, Anne von Gottberg, Richard Lessells, Houriiyah Tegally, Tulio de Oliveira   +31 more
doaj   +1 more source

Asimov's Coming Back [PDF]

, 2006
Ever since the word ‘ROBOT’ first appeared in a science\ud fiction in 1921, scientists and engineers have been trying\ud different ways to create it. Present technologies in\ud mechanical and electrical engineering makes it possible\ud to have robots in ...
Wang, Mr. L.
core  

Trajectories of Physical Function in Canadian Children with Juvenile Idiopathic Arthritis

Arthritis Care &Research, Accepted Article.
Objectives We describe trajectories of physical function in children newly diagnosed with juvenile idiopathic arthritis (JIA) and identify trajectories with persisting functional impairments and associated baseline characteristics. Methods We included patients enrolled in the Canadian Alliance of Pediatric Rheumatology Investigators (CAPRI) Registry ...
Clare Cunningham, Meghan McPherson, Lillian Lim, Roberta A. Berard, Matthew Berkowitz, Jean‐Philippe Proulx‐Gauthier, Brian M. Feldman, Nicole Johnson, Dax G. Rumsey, Heinrike Schmeling, Lori B. Tucker, Thomas Loughin, Kristin M. Houghton, Jaime Guzman, The CAPRI Registry Investigators   +14 more
wiley   +1 more source

Multidrug-Resistant Virulent Escherichia coli Strains in Cattle: Implications on Food Safety and Public Health

International Journal of Microbiology
Escherichia coli inhabit the gastrointestinal tract of mammals, including cattle, where they occur as commensals. However, some strains have evolved as highly virulent pathogens that also harbor a variety of multidrug-resistant determinants.
Ajay Kumar, Emmanuel W. Bumunang, Peter Kotsoana Montso, Smriti Singh, Collins Njie Ateba   +4 more
doaj   +1 more source