Results 91 to 100 of about 2,598,515 (356)

Navigating the bridge between wet and dry lab toxicology research to address current challenges with high-dimensional data

Frontiers in Toxicology, 2023
Toxicology research has rapidly evolved, leveraging increasingly advanced technologies in high-throughput approaches to yield important information on toxicological mechanisms and health outcomes. Data produced through toxicology studies are consequently
Alexis Payton, Alexis Payton, Kyle R. Roell, Kyle R. Roell, Meghan E. Rebuli, Meghan E. Rebuli, Meghan E. Rebuli, William Valdar, Ilona Jaspers, Ilona Jaspers, Ilona Jaspers, Ilona Jaspers, Julia E. Rager, Julia E. Rager, Julia E. Rager, Julia E. Rager   +15 more
doaj   +1 more source

The use of a quantitative structure-activity relationship (QSAR) model to predict GABA-A receptor binding of newly emerging benzodiazepines [PDF]

, 2018
The illicit market for new psychoactive substances is forever expanding. Benzodiazepines and their derivatives are one of a number of groups of these substances and thus far their number has grown year upon year.
Haegeman, Caroline, Haider, Shozeb, Manchester, Kieran R., Maskell, Peter D., Waters, Laura   +4 more
core   +4 more sources

Bionic Nanostructures Create Mechanical Signals to Mediate the Composite Structural Bone Regeneration Through Multi‐System Regulation

Advanced Science, EarlyView.
Inspired by the structural and functional characteristics of bone, bionic nanomaterials combined with nanotechnology can more accurately replicate stem cell niches, enabling the design of bone tissue engineering scaffolds with diverse nanoscale properties to promote stem cell migration, proliferation, and differentiation. This precise control over stem
Yangfan Pei, Yihan Wang, Jingxia Chen, Jing Zhou, Yuzhu Han, Xiuyu Liu, Siyu Chen, Sheng Chen, Dixin He, Yunxiao Wu, Huixin Lv, Yanmin Zhou   +11 more
wiley   +1 more source

SF3A3 Drives Tumorigenesis in Endometrial Cancer by Enhancing c‐FOS Expression and Represents a Potential Therapeutic Target

Advanced Science, EarlyView.
The role of splicing factor 3A subunit 3 (SF3A3) in driving endometrial cancer (EC) progression and potential therapeutic interventions. SF3A3, a core component of the U2 small nuclear ribonucleoprotein (U2 snRNP), is upregulated in endometrial cancer (EC) and promotes tumor growth and cisplatin resistance. RNA‐binding protein immunoprecipitation (RIP)
Wei Yu, Yi Gu, Hengrui Zhang, Wunan Huang, Lei Sun, Liangjian Ma, Xiaolei Liang, Lexin Liu, Guiping Chen, Weihua Wang, Zhongkai Cao, Xue Li, Xiangjun Chen, Lidan Hu   +13 more
wiley   +1 more source

Adaptive Machine Learning for Electronic Nose‐Based Forensic VOC Classification

Advanced Science, EarlyView.
A 32‐element electronic nose enhanced with machine learning demonstrates exceptional accuracy in differentiating between living and deceased individuals (98.1%), discriminating human and animal specimens (97.2%), and estimating postmortem intervals.
Ivan Shtepliuk, Kerstin Montelius, Jens Eriksson, Donatella Puglisi   +3 more
wiley   +1 more source

Remote Control of Eukaryotic Gene Expression by a Modular Ultrasound‐Responsive RNA Toolkit

Angewandte Chemie, EarlyView.
A modular RNA‐based sonogenetic toolkit enables remote control of gene expression in eukaryotes by releasing small molecule modulators from ultrasound‐responsive carriers. These modulators activate engineered mRNA elements such as riboswitches, leading to tunable protein expression.
Fahimeh Charbgoo, Aman Ishaqat, Junlin Chen, Fabian Wiertz, Adrian Kuzmanović, Matthias Bartneck, Fabian Kiessling, Andreas Herrmann   +7 more
wiley   +2 more sources

In silico toxicology models and databases as FDA Critical Path Initiative toolkits

Human Genomics, 2011
In silico toxicology methods are practical, evidence-based and high throughput, with varying accuracy. In silico approaches are of keen interest, not only to scientists in the private sector and to academic researchers worldwide, but also to the public ...
Valerio Luis G
doaj   +1 more source

Supplement use in sport: is there a potentially dangerous incongruence between rationale and practice? [PDF]

, 2007
BACKGROUND: Supplement use by athletes is complex and research supports the alarming notion of misinformed decisions regarding supplements. HYPOTHESIS: A frequent divergence between the type of supplements chosen by athletes and the rationale dictating ...
Naughton, Declan, Petróczi, Andrea
core   +2 more sources

A Novel Class of Multi‐substituted Diaryl Scaffold Derivatives Inhibit Glioblastoma Progression by Targeting CD155

Advanced Science, EarlyView.
Structural modification of clofoctol yielded a novel blood‐brain barrier‐permeable compound, B7, featuring a multi‐substituted diaryl scaffold. B7 demonstrates potent anti‐glioblastoma activity by suppressing glioblastoma stem cells proliferation, migration, and invasion through interactions with five key residues of poliovirus receptor cell adhesion ...
Yong‐jian Wang, Ting Sun, Si‐tu Xue, Zhong‐di Cai, Hong Yi, Miao Lv, Shi‐bo Kou, Rui Liu, Xiao‐zhong Peng, Zhuo‐rong Li   +9 more
wiley   +1 more source

Ginsenosides are novel naturally-occurring aryl hydrocarbon receptor ligands. [PDF]

, 2013
The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that mediates many of the biological and toxicological actions of structurally diverse chemicals.
Bonati, Laura, Denison, Michael S, Fraccalvieri, Domenico, He, Guochun, Hu, Qin, Soshilov, Anatoly, Xie, Qunhui, Yin, Huijun, Zhang, Aiqian, Zhao, Bin, Zhao, Jing   +10 more
core   +3 more sources