Results 101 to 110 of about 3,045,461 (301)

Current status and future perspective of computational toxicology in drug safety assessment under ontological intellection.

Journal of Toxicological Sciences, 2019
For the safety assessment of pharmaceuticals, initial data management requires accurate toxicological data acquisition, which is based on regulatory safety studies according to guidelines, and computational systems have been developed under the ...
Yuki Yamagata, H. Yamada, I. Horii
semanticscholar   +1 more source

CoMPARA: Collaborative Modeling Project for Androgen Receptor Activity (COMPARA) Data: Individual models

, 2019
Data and supplemental files from COMPARA (A large-scale modeling project). COMPARA combined multiple models developed in collaboration with modelers and computational toxicology scientists from 25 international groups to predict androgen receptor ...
EPA's Center for Computational Toxicology and Exposure (7878288)
core   +1 more source

CoMPARA: Collaborative Modeling Project for Androgen Receptor Activity (COMPARA) Data:Training Set+Prediction Set

, 2019
Data and supplemental files from COMPARA (A large-scale modeling project). COMPARA combined multiple models developed in collaboration with modelers and computational toxicology scientists from 25 international groups to predict androgen receptor ...
EPA's Center for Computational Toxicology and Exposure (7878288)
core   +1 more source

Predicting toxicity of chemicals: software beats animal testing

EFSA Journal, 2019
We created earlier a large machine‐readable database of 10,000 chemicals and 800,000 associated studies by natural language processing of the public parts of Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) registrations until
Thomas Hartung
doaj   +1 more source

Analysis of biomarker utility using a PBPK/PD model for carbaryl

Frontiers in Pharmacology, 2014
There are many types of biomarkers; the two common ones are biomarkers of exposure and biomarkers of effect. The utility of a biomarker for estimating exposures or predicting risks depends on the strength of the correlation between biomarker ...
Martin Blake Phillips, Miyoung eYoon, Bruce eYoung, Yu-Mei eTan   +3 more
doaj   +1 more source

Chapter 4. Integrated Translation Framework for Endocrine Disruptors in the area of Computational Toxicology

, 2020
In the recent past, there has been a tremendous increase in the kind of data being generated by high-throughput analysis (omics) for endocrine disruptors (EDs).
Vinay Kumar, D. Deepika, R. Sharma
semanticscholar   +1 more source

Embedding Chemistry and Pharmacy Into Sustainability

Angewandte Chemie International Edition, EarlyView.
Chemistry and pharmacy provide products and processes that are indispensable for our high living standard. To understand their relationship with sustainability is important to allow them to contribute to sustainability in a sustainable manner. An integrated overview of green, circular, and sustainable chemistry and pharmacy is given and how they have t
Klaus Kümmerer
wiley   +1 more source

A new approach methodology to identify tumorigenic chemicals using short-term exposures and transcript profiling

Frontiers in Toxicology
Current methods for cancer risk assessment are resource-intensive and not feasible for most of the thousands of untested chemicals. In earlier studies, we developed a new approach methodology (NAM) to identify liver tumorigens using gene expression ...
Victoria Ledbetter, Victoria Ledbetter, Scott Auerbach, Logan J. Everett, Beena Vallanat, Anna Lowit, Gregory Akerman, William Gwinn, Leah C. Wehmas, Michael F. Hughes, Michael Devito, J. Christopher Corton   +11 more
doaj   +1 more source

Interrogating health-related public databases from a food toxicology perspective: Computational analysis of scoring data

, 2011
Over the last 15 years, an expanding number of databases with information on noxious effects of substances on mammalian organisms and the environment have been made available on the Internet.
U. Hammerling, Malm, Patrik,, D. Soeria-Atmadja, M.G. Gustafsson, Soeria-Atmadja, Daniel, Maddah, Farzaneh, Gustafsson, Mats G.,, F. Maddah, Hammerling, Ulf, P. Malm   +9 more
core   +1 more source

Computational toxicology using OpenTox & Bioclipse

, 2012
Computational methods, e.g., OECD QSAR Toolbox and ToxPredict, are increasingly used to support chemicals toxicity assessment in academic settings, industry and governments.
Willighagen, E, Willighagen, Egon, Grafström, Roland, Sjuth, O, Grafstrom, R, Spjuth, Ola,   +5 more
core   +1 more source