Results 101 to 110 of about 1,723,253 (280)

Systems toxicology: real world applications and opportunities [PDF]

, 2017
Systems Toxicology aims to change the basis of how adverse biological effects of xenobiotics are characterized from empirical end points to describing modes of action as adverse outcome pathways and perturbed networks. Toward this aim, Systems Toxicology
Peitsch, Manuel C, Shah, Imran, Sturla, Shana J.; id_orcid, Rex E. FitzGerald, Amin Rostami-Hodjegan, FitzGerald, Rex E., Mirams, Gary R, Sturla, Shana J., Thomas Hartung, Paul Jennings, FitzGerald, Rex E, Wilks, Martin F, Martin F. Wilks, Rostami-Hodjegan, Amin, Shana J. Sturla, Gary R. Mirams, Manuel C. Peitsch, Peitsch, Manuel C., Mirams, Gary R., Imran Shah, Hartung, Thomas, Jennings, Paul, Jennings, Paul; id_orcid, Sturla, Shana J, Wilks, Martin F., Jennings P, Hartung T, FitzGerald RE, Shah I, Wilks MF, Sturla SJ, Peitsch MC, Rostami-Hodjegan A, Mirams GR   +33 more
core   +1 more source

Capacity building in medicines development and regulation in Africa—Overview on recent progress

British Journal of Clinical Pharmacology, EarlyView.
Aims Despite advances in health research and digital innovation, many African countries continue to face substantial resource constraints, fragmented capacity‐building efforts and a shortage of skilled professionals in medicines development and regulatory science.
Tirhani Maluleke, Emile Malan, Michael Reid, Patrick Bouic, Haylene Nell, Goonaseelan Pillai, Catriona Waitt, Bernd Rosenkranz   +7 more
wiley   +1 more source

The Chemical and Products Database v4.0, an updated resource supporting chemical exposure evaluations

Scientific Data
Since the initial release of the Chemical and Products Database (CPDat) in 2018, the United States Environmental Protection Agency has added a considerable amount of chemical exposure-related information to the database and has expanded its schema to ...
Sakshi Handa, Kristin K. Isaacs, Jonathan T. Wall, Allison Larger, Scott Burns, Lauren E. Koval, Kenta Baron-Furuyama, Colleen M. Elonen, David Lyons, Kathie L. Dionisio, M. Beth Horton, Katherine A. Phillips   +11 more
doaj   +1 more source

Introduction to Special Issue: Computational Toxicology [PDF]

Chemical Research in Toxicology, 2021
Nicole C. Kleinstreuer, Igor V. Tetko, Weida Tong   +2 more
openaire   +3 more sources

Occupational toxicology - to include biomarkers.

, 2013
Lecture di Occupational Toxicology in Master Internazionale di Applied ...
MANNO, MAURIZIO
core  

Structural improvement of higher education in environmental toxicology in Latin America and Europe

, 2000
The paper reports the results of an international, EU-supported concerted action between Europe and Latin America involving 13 academic institutions from 10 different countries (5 from Europe and 5 from Latin America) aiming to develop a joint core ...
CEBRIAN M. E., JARAMILLO JUAREZ F., FOWLER J., MANNO, MAURIZIO, BARRIL ANTUNA J., OLARTE G., DEKANT W., ALBORES A., GIL L., DE MATTEIS F., TORRES ALANIS O., DIAZ BARRIGA F., KING L., PATINO R. I., OSTROSKY WEGMAN P., Fowler, J., Jaramillo-Juárez, F., Barril-Antuña, J., Manno, M., Cebrián, M. E., Torres-Alanı́s, O., Gil, L., Patño, R. I., Ostrosky-Wegman, P., De Matteis, F., Dekant, W., Kingi, L. J., Albores, A., Diaz-Barriga, F., Olarte, G., M. Manno, A. Albores, F. De Matteis, W. Dekant, F. Jaramillo-Juárez, M.E. Cebrián, F. Diaz-Barriga, P. Ostrosky-Wegman, J. Barril-Antuña, L. Gil, L.J. King, J. Fowler, R.I. Patño, O. Torres-Alanı́s, G. Olarte   +44 more
core   +1 more source

Re‐evaluating variability of circulating miR‐122 in healthy volunteers: Implications for biomarker qualification in drug‐induced liver injury

British Journal of Clinical Pharmacology, EarlyView.
Drug‐induced liver injury (DILI) remains a major challenge in clinical practice and drug development, and reliable biomarkers are still needed. MicroRNA‐122 (miR‐122) has shown promise, but reported inter‐individual variability in healthy populations has raised concerns about its clinical utility.
Irum Javid, Giusy Russomanno, Anthony Evans, Guruprasad P. Aithal, Shiva S. Forootan, Warren E. Glaab, Matthias Hackl, Joely Irlam, Kseniya Khamina‐Kotisch, Samantha Korver, Gerd A. Kullak‐Ublick, Sophia L. Samodelov, Christopher E. Goldring   +12 more
wiley   +1 more source

Computational Toxicology: A New Frontier in Predictive Toxicology

International Journal of Innovative Research in Computer and Communication Engineering
Computational toxicology, a field that bridges toxicology with computational tools, is transforming how adverse effects of chemicals on human health and the environment are predicted. This innovative approach reduces reliance on animal testing, accelerates safety assessments, and lowers costs for industries like pharmaceuticals and environmental ...
C K Gomathy, V Geetha, H. Surendar, S. Sri Ramakrishnan, V. Sanjay   +4 more
openaire   +1 more source

A novel infrastructure for chemical safety predictions with focus on human health

, 2012
A major objective of Computational Toxicology is to provide reliable and useful estimates in silico of (potentially) harmful actions of chemicals in humans.
Dencker, L, Willighagen, Egon,, Willighagen, E, Grafström, Roland,, Hammerling, U, Grafstrom, R, Spjuth, Ola,, Hammerling, Ulf,, Dencker, Lennart,, Spjuth, O   +9 more
core   +1 more source

Unsupervised machine learning for multi‐system adverse event pattern detection in pharmacovigilance: A proof‐of‐concept analysis of fluoroquinolone reports in FAERS

British Journal of Clinical Pharmacology, EarlyView.
. Aims Traditional pharmacovigilance detects single drug–event associations but cannot readily characterize multi‐system adverse‐event patterns such as fluoroquinolone‐associated disability. We evaluated unsupervised machine learning for this purpose, using fluoroquinolones as an exemplar.
Niaz Chalabianloo, Sheikh S. Abdullah, Kamran Sedig, Flory T. Muanda   +3 more
wiley   +1 more source