Results 51 to 60 of about 72,918 (293)

Kidney Organoids in Drug Development: Integrating Technological Advances and Standardization for Effective Implementation

Advanced Healthcare Materials, EarlyView.
This review examines how emerging enabling technologies enhance the physiological relevance, scalability, and reproducibility of kidney organoids, while advanced analytical approaches support model validation and deepen mechanistic insight into nephrotoxicity.
Helen Kearney, Silvia M. Mihăilă, Lorenzo Moroni, Carlos Mota   +3 more
wiley   +1 more source

Metabolic Patterning on a Chip: Towards in vitro Liver Zonation of Primary Rat and Human Hepatocytes

, 2018
An important number of healthy and diseased tissues shows spatial variations in their metabolic capacities across the tissue. The liver is a prime example of such heterogeneity where the gradual changes in various metabolic activities across the liver ...
Eo, Jinsu, Kang, Young Bok (Abraham), Mert, Safak, Usta, O. Berk, Yarmush, Martin L.   +4 more
core   +1 more source

Microbubble Shell Stiffness Engineering Enhances Ultrasound Imaging, Drug Delivery, and Sonoporation

Advanced Materials, EarlyView.
 Shell‐engineered poly(alkyl cyanoacrylate) microbubbles with tunable stiffness improve ultrasound imaging and therapy. Adjusting the length of the alkyl chain and the glass transition temperature maintains a narrow microbubble size distribution while enhancing drug loading, sonoporation and the acoustic response.
Roman A. Barmin, MirJavad Moosavifar, Elena Rama, Julia Blöck, Anne Rix, Vladislav S. Petrovskii, Rustam A. Gumerov, Jens Köhler, Michael Pohl, Céline Bastard, Stephan Rütten, Laura Charlton, Vu Ngoc Khiêm, Fabio Domenici, Thomas Lisson, Ekaterina Savina, Rui Zhang, Jasmin Baier, Susanne Koletnik, Vasileios Koutsos, Mikhail Itskov, Gaio Paradossi, Georg Schmitz, Tina Vermonden, Laura De Laporte, Robert Göstl, Andreas Herrmann, Igor I Potemkin, Fabian Kiessling, Twan Lammers, Roger M. Pallares   +30 more
wiley   +1 more source

Computational drug repositioning approach to predict multi-target therapeutics for epilepsy

Scientific Reports
Epilepsy affects millions of people globally, with approximately one-third of patients experiencing drug-resistant seizures. Developing new anti-epileptic drugs is time-intensive and costly, prompting interest in computational drug repositioning ...
Pawan Kumar, Vivek Kumar, Raveena Chauhan, Vandana Saini, Ajit Kumar   +4 more
doaj   +1 more source

Using Zebrafish to Screen Developmental Toxicity of Per- and Polyfluoroalkyl Substances (PFAS)

Toxics
Per- and polyfluoroalkyl substances (PFAS) are found in many consumer and industrial products. While some PFAS, notably perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS), are developmentally toxic in mammals, the vast majority of PFAS
Katy N. Britton, Richard S. Judson, Bridgett N. Hill, Kimberly A. Jarema, Jeanene K. Olin, Bridget R. Knapp, Morgan Lowery, Madison Feshuk, Jason Brown, Stephanie Padilla   +9 more
doaj   +1 more source

Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects

Advanced Materials, EarlyView.
Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley   +1 more source

Multiplexed Luminal Tissue Constructs with Reconfigurable Barriers for Dynamic Modeling of Multi‐Tissue Interactions

Advanced Materials Technologies, EarlyView.
This study describes the fabrication of arrays of luminal tissue constructs for 3D luminal tissue modeling. An oil or media‐filled reservoir between constructs serves as a liquid barrier or bridge to regulate communication between lumens within the array for modeling multi‐tissue interactions in vitro. Abstract Cell‐lined luminal structures are crucial
Mouhita Humayun, José A. Jiménez‐Torres, Chao Li, Jose M. Ayuso, Karina Lugo‐Cintron, Joseph Ulbrich, Benjamin Myers, Sheena C. Kerr, Adeel Ahmed, David J. Beebe   +9 more
wiley   +1 more source

Harvesting the Promise of AOPs: An assessment and recommendations [PDF]

, 2018
The Adverse Outcome Pathway (AOP) concept is a knowledge assembly and communication tool to facilitate the transparent translation of mechanistic information into outcomes meaningful to the regulatory assessment of chemicals.
Ankley, Gerald T., Carusi, Annamaria, Davies, Mark R., De Grandis, Giovanni De, Escher, Beate I., Hodges, Geoff, Wheelan, Maurice, Willet, Catherine, Y. Leung, Kenneth M.   +8 more
core   +4 more sources

Spectroscopic Ellipsometry Characterization and Radiative Limit Modeling of Bismuth‐Based Perovskite‐Inspired Absorbers for Indoor Photovoltaics

Advanced Optical Materials, EarlyView.
This study determines the optical constants of two lead‐free perovskite‐inspired materials (PIMs), Cu2AgBiI6 and Cs3Bi2I6Br3, promising for indoor light conversion. The optical constants are applied to simulate photovoltaic device optics, and thereupon, revise the theoretical limits for photocurrent generation and power conversion efficiency, providing
Aleksi Kamppinen, G. Krishnamurthy Grandhi, Mahboubeh Hadadian, Sami Toikkonen, Sirius Yli‐Paavola, Paola Vivo, Kati Miettunen   +6 more
wiley   +1 more source

Decoding DNA damage: artificial intelligence and the future of genotoxicity assessment

All Life
Genotoxicity assessment is a cornerstone of chemical safety, yet conventional bioassays are often constrained by high costs, ethical concerns, and suboptimal human risk predictivity. The integration of computational toxicology and artificial intelligence
Ehsan Ghassemi Barghi, Farzaneh Motafeghi, Jafar Gholami Gharab, Nasrin Ghassemi Barghi   +3 more
doaj   +1 more source