Results 31 to 40 of about 3,045,461 (301)

Annotation depth confounds direct comparison of gene expression across species

BMC Bioinformatics, 2021
Background Comparisons of the molecular framework among organisms can be done on both structural and functional levels. One of the most common top-down approaches for functional comparisons is RNA sequencing. This estimation of organismal transcriptional
Elias Oziolor, Seda Arat, Matthew Martin
doaj   +1 more source

Developmental Neurotoxicity and Behavioral Screening in Larval Zebrafish with a Comparison to Other Published Results

Toxics, 2022
With the abundance of chemicals in the environment that could potentially cause neurodevelopmental deficits, there is a need for rapid testing and chemical screening assays.
Kimberly A. Jarema, Deborah L. Hunter, Bridgett N. Hill, Jeanene K. Olin, Katy N. Britton, Matthew R. Waalkes, Stephanie Padilla   +6 more
doaj   +1 more source

Estimating provisional margins of exposure for data-poor chemicals using high-throughput computational methods

Frontiers in Pharmacology, 2022
Current computational technologies hold promise for prioritizing the testing of the thousands of chemicals in commerce. Here, a case study is presented demonstrating comparative risk-prioritization approaches based on the ratio of surrogate hazard and ...
Chantel I. Nicolas, Matthew W. Linakis, Melyssa S. Minto, Kamel Mansouri, Rebecca A. Clewell, Miyoung Yoon, John F. Wambaugh, Grace Patlewicz, Patrick D. McMullen, Melvin E. Andersen, Harvey J. Clewell III   +10 more
doaj   +1 more source

Artificial intelligence as the new frontier in chemical risk assessment

Frontiers in Artificial Intelligence, 2023
The rapid progress of AI impacts various areas of life, including toxicology, and promises a major role for AI in future risk assessments. Toxicology has shifted from a purely empirical science focused on observing chemical exposure outcomes to a data ...
Thomas Hartung, Thomas Hartung
doaj   +1 more source

Systems toxicology: real world applications and opportunities [PDF]

, 2017
Systems Toxicology aims to change the basis of how adverse biological effects of xenobiotics are characterized from empirical end points to describing modes of action as adverse outcome pathways and perturbed networks. Toward this aim, Systems Toxicology
Peitsch, Manuel C, Shah, Imran, Sturla, Shana J.; id_orcid, Rex E. FitzGerald, Amin Rostami-Hodjegan, FitzGerald, Rex E., Mirams, Gary R, Sturla, Shana J., Thomas Hartung, Paul Jennings, FitzGerald, Rex E, Wilks, Martin F, Martin F. Wilks, Rostami-Hodjegan, Amin, Shana J. Sturla, Gary R. Mirams, Manuel C. Peitsch, Peitsch, Manuel C., Mirams, Gary R., Imran Shah, Hartung, Thomas, Jennings, Paul, Jennings, Paul; id_orcid, Sturla, Shana J, Wilks, Martin F.   +24 more
core   +1 more source

High-throughput toxicogenomic screening of chemicals in the environment using metabolically competent hepatic cell cultures

npj Systems Biology and Applications, 2021
The ToxCast in vitro screening program has provided concentration-response bioactivity data across more than a thousand assay endpoints for thousands of chemicals found in our environment and commerce.
Jill A. Franzosa, Jessica A. Bonzo, John Jack, Nancy C. Baker, Parth Kothiya, Rafal P. Witek, Patrick Hurban, Stephen Siferd, Susan Hester, Imran Shah, Stephen S. Ferguson, Keith A. Houck, John F. Wambaugh   +12 more
doaj   +1 more source

Toxicity prediction: An application of alternative testing and computational toxicology in contaminated groundwater sites in Taiwan.

Journal of Environmental Management, 2022
Groundwater contamination remains a global threat due to its toxic effects to humans and the environment. The remediation of contaminated groundwater sites can be costly, thus, identifying the priority areas of concern is important to reduce money spent ...
Rachelle D. Arcega, Rong Chen, Pei-Shan Chih, Yi-Hsuan Huang, Weiping Chang, Ting Kong, Ching‐Chang Lee, T. Mahmudiono, Chun-Chih Tsui, Wen-Che Hou, H. Hsueh, Hsiu‐Ling Chen   +11 more
semanticscholar   +1 more source

Accessing, using, and creating chemical property databases for computational toxicology modeling

, 2012
Toxicity data is expensive to generate, is increasingly seen as precompetitive, and is frequently used for the generation of computational models in a discipline known as computational toxicology.
Williams, Anthony J.,, Ekins, Sean,, Willighagen, Egon L.,, Spjuth, Ola,   +3 more
core   +3 more sources

Proteomics for systems toxicology

Computational and Structural Biotechnology Journal, 2014
Current toxicology studies frequently lack measurements at molecular resolution to enable a more mechanism-based and predictive toxicological assessment.
Bjoern Titz, Ashraf Elamin, Florian Martin, Thomas Schneider, Sophie Dijon, Nikolai V. Ivanov, Julia Hoeng, Manuel C. Peitsch   +7 more
doaj   +1 more source

Consideration of predicted small-molecule metabolites in computational toxicology

Digital Discovery, 2022
Exploration of computational approaches for including metabolism information in machine learning models for toxicity prediction.
M. Garcia de Lomana, Fredrik Svensson, Andrea Volkamer, M. Mathea, J. Kirchmair   +4 more
semanticscholar   +1 more source