Results 21 to 30 of about 21,882 (246)

A Combined In Vitro/In Silico Approach to Identifying Off-Target Receptor Toxicity

iScience, 2018
Summary: Many xenobiotics can bind to off-target receptors and cause toxicity via the dysregulation of downstream transcription factors. Identification of subsequent off-target toxicity in these chemicals has often required extensive chemical testing in ...
Joseph Leedale, Kieran J. Sharkey, Helen E. Colley, Áine M. Norton, David Peeney, Chantelle L. Mason, Jean G. Sathish, Craig Murdoch, Parveen Sharma, Steven D. Webb   +9 more
doaj   +1 more source

High-throughput toxicogenomic screening of chemicals in the environment using metabolically competent hepatic cell cultures

npj Systems Biology and Applications, 2021
The ToxCast in vitro screening program has provided concentration-response bioactivity data across more than a thousand assay endpoints for thousands of chemicals found in our environment and commerce.
Jill A. Franzosa, Jessica A. Bonzo, John Jack, Nancy C. Baker, Parth Kothiya, Rafal P. Witek, Patrick Hurban, Stephen Siferd, Susan Hester, Imran Shah, Stephen S. Ferguson, Keith A. Houck, John F. Wambaugh   +12 more
doaj   +1 more source

High-throughput AR dimerization assay identifies androgen disrupting chemicals and metabolites

Frontiers in Toxicology, 2023
Introduction: Analysis of streamlined computational models used to predict androgen disrupting chemicals revealed that assays measuring androgen receptor (AR) cofactor recruitment/dimerization were particularly indispensable to high predictivity ...
Evan C. Brown, Evan C. Brown, Daniel R. Hallinger, Steven O. Simmons   +3 more
doaj   +1 more source

Antidiabetic activity of avocado seeds (Persea americana Mill.) in diabetic rats via activation of PI3K/AKT signaling pathway

Scientific Reports, 2022
The treatment of diabetes involves the use of herbal plants, attracting interest in their cost-effectiveness and efficacy. An aqueous extract of Persea americana seeds (AEPAS) was explored in this study as a possible therapeutic agent in rats with ...
Oluwafemi Adeleke Ojo, Jennifer Chidubem Amanze, Abosede Itunuoluwa Oni, Susan Grant, Matthew Iyobhebhe, Tobiloba Christiana Elebiyo, Damilare Rotimi, Nnaemeka Tobechukwu Asogwa, Babatunji Emmanuel Oyinloye, Basiru Olaitan Ajiboye, Adebola Busola Ojo   +10 more
doaj   +1 more source

Computational toxicology using the OpenTox application programming interface and Bioclipse

BMC Research Notes, 2011
Background Toxicity is a complex phenomenon involving the potential adverse effect on a range of biological functions. Predicting toxicity involves using a combination of experimental data (endpoints) and computational methods to generate a set of ...
Willighagen Egon L, Jeliazkova Nina, Hardy Barry, Grafström Roland C, Spjuth Ola   +4 more
doaj   +1 more source

The CompTox Chemistry Dashboard: a community data resource for environmental chemistry

Journal of Cheminformatics, 2017
Despite an abundance of online databases providing access to chemical data, there is increasing demand for high-quality, structure-curated, open data to meet the various needs of the environmental sciences and computational toxicology communities.
Antony J. Williams, Christopher M. Grulke, Jeff Edwards, Andrew D. McEachran, Kamel Mansouri, Nancy C. Baker, Grace Patlewicz, Imran Shah, John F. Wambaugh, Richard S. Judson, Ann M. Richard   +10 more
doaj   +1 more source

Optimization of Human Neural Progenitor Cells for an Imaging-Based High-Throughput Phenotypic Profiling Assay for Developmental Neurotoxicity Screening

Frontiers in Toxicology, 2022
Studies in in vivo rodent models have been the accepted approach by regulatory agencies to evaluate potential developmental neurotoxicity (DNT) of chemicals for decades. These studies, however, are inefficient and cannot meet the demand for the thousands
Megan Culbreth, Johanna Nyffeler, Johanna Nyffeler, Clinton Willis, Joshua A. Harrill   +4 more
doaj   +1 more source

Male fathead minnow transcriptomes and associated chemical analytes in the Milwaukee estuary system

Scientific Data, 2022
Measurement(s) transcripts • water chemistry Technology Type(s) RNAseq • GC/MS Factor Type(s) exposure Sample Characteristic - Organism Pimephales promelas Sample Characteristic - Environment estuary system Sample Characteristic - Location Milwaukee, WI,
Natàlia Garcia-Reyero, Mark A. Arick, E. Alice Woolard, Mitchell Wilbanks, John E. Mylroie, Kathleen Jensen, Michael Kahl, David Feifarek, Shane Poole, Eric Randolph, Jenna Cavallin, Brett R. Blackwell, Daniel Villeneuve, Gerald T. Ankley, Edward J. Perkins   +14 more
doaj   +1 more source

Leveraging a High-Throughput Screening Method to Identify Mechanisms of Individual Susceptibility Differences in a Genetically Diverse Zebrafish Model

Frontiers in Toxicology, 2022
Understanding the mechanisms behind chemical susceptibility differences is key to protecting sensitive populations. However, elucidating gene-environment interactions (GxE) presents a daunting challenge.
Dylan J. Wallis, Jane La Du, Preethi Thunga, Daniel Elson, Lisa Truong, Siva K. Kolluri, Robyn L. Tanguay, David M. Reif   +7 more
doaj   +1 more source

Progress in computational toxicology

Journal of Pharmacological and Toxicological Methods, 2014
A poster in the ToxI division at the ACS held in SF ...
openaire   +2 more sources