From prediction to adaptation: rethinking the epistemic role of inhalation toxicology [PDF]
Frontiers in ToxicologyInhalation toxicology has long aimed to predict the health effects of airborne substances before exposure occurs, relying on stable dose-response relationships and well-characterized hazards.
Samir Dekali
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Towards Explainable Computational Toxicology: Linking Antitargets to Rodent Acute Toxicity [PDF]
PharmaceuticsObjectives: One of the major trends in modern computational toxicology is the development of explainable predictive tools. However, the complex nature of the mechanistic representation of biological organisms and the lack of relevant data remain limiting
Ilia Nikitin +4 more
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The digital evolution in toxicology: pioneering computational education for emerging challenges
BMC Medical EducationThe educational landscape of toxicology is increasingly integrating computational methodologies due to ethical concerns about animal testing and advancements in biotechnological and data analysis tools.
Jin Wang, Jianxiang Li
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Computational toxicology [PDF]
Human and Experimental Toxicology, 2015 Predictive toxicology plays a critical role in reducing the failure rate of new drugs in pharmaceutical research and development. Despite recent gains in our understanding of drug-induced toxicity, however, it is urgent that the utility and limitations of our current predictive tools be determined in order to identify gaps in our understanding of ...
R T, Naven, S, Louise-May
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Efficiency of pharmaceutical toxicity prediction in computational toxicology. [PDF]
Toxicol ResUesawa Y.
europepmc +2 more sources
Introduction to Special Issue: Computational Toxicology [PDF]
Chemical Research in Toxicology, 2021 Nicole C. Kleinstreuer +2 more
openaire +4 more sources
A Survey of Computational Toxicology Approaches [PDF]
Kafrelsheikh Journal of Information Sciences, 2021 Medications are a particular kind of chemicals that are considered essential for toxicity screening in contrast to those substances that contribute to the environment.
Amena Mahmoud
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Big-data and machine learning to revamp computational toxicology and its use in risk assessment. [PDF]
Toxicol Res (Camb), 2018 Luechtefeld T, Rowlands C, Hartung T.
europepmc +2 more sources
Predicting molecular initiating events using chemical target annotations and gene expression
BioData Mining, 2022 Background The advent of high-throughput transcriptomic screening technologies has resulted in a wealth of publicly available gene expression data associated with chemical treatments.
Joseph L. Bundy +5 more
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A harmonized chemical monitoring database for support of exposure assessments
Scientific Data, 2022 Measurement(s) occurrence of chemicals in environmental and biological media Technology Type(s) mass spectrometry (curation of public data) Sample Characteristic - Organism Homo sapiens • aquatic invertebrates • aquatic vertebrates/mammals • birds • fish
Kristin K. Isaacs +12 more
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