Results 41 to 50 of about 3,045,461 (301)

A Combined In Vitro/In Silico Approach to Identifying Off-Target Receptor Toxicity

iScience, 2018
Summary: Many xenobiotics can bind to off-target receptors and cause toxicity via the dysregulation of downstream transcription factors. Identification of subsequent off-target toxicity in these chemicals has often required extensive chemical testing in ...
Joseph Leedale, Kieran J. Sharkey, Helen E. Colley, Áine M. Norton, David Peeney, Chantelle L. Mason, Jean G. Sathish, Craig Murdoch, Parveen Sharma, Steven D. Webb   +9 more
doaj   +1 more source

High-throughput AR dimerization assay identifies androgen disrupting chemicals and metabolites

Frontiers in Toxicology, 2023
Introduction: Analysis of streamlined computational models used to predict androgen disrupting chemicals revealed that assays measuring androgen receptor (AR) cofactor recruitment/dimerization were particularly indispensable to high predictivity ...
Evan C. Brown, Evan C. Brown, Daniel R. Hallinger, Steven O. Simmons   +3 more
doaj   +1 more source

Antidiabetic activity of avocado seeds (Persea americana Mill.) in diabetic rats via activation of PI3K/AKT signaling pathway

Scientific Reports, 2022
The treatment of diabetes involves the use of herbal plants, attracting interest in their cost-effectiveness and efficacy. An aqueous extract of Persea americana seeds (AEPAS) was explored in this study as a possible therapeutic agent in rats with ...
Oluwafemi Adeleke Ojo, Jennifer Chidubem Amanze, Abosede Itunuoluwa Oni, Susan Grant, Matthew Iyobhebhe, Tobiloba Christiana Elebiyo, Damilare Rotimi, Nnaemeka Tobechukwu Asogwa, Babatunji Emmanuel Oyinloye, Basiru Olaitan Ajiboye, Adebola Busola Ojo   +10 more
doaj   +1 more source

Simultaneous non-negative matrix factorization for multiple large scale gene expression datasets in toxicology [PDF]

, 2012
Non-negative matrix factorization is a useful tool for reducing the dimension of large datasets. This work considers simultaneous non-negative matrix factorization of multiple sources of data.
Clare M. Lee, Vass J. Keith, D R Haggart, Lee Clare M., Mudaliar, MAV, Higham, Desmond, Vass, D.J., Manikhandan A V Mudaliar, Gino Miele, Mudaliar, Manikhandan A.V., Haggart, D. R., Mudaliar, M.A.V., Higham, Desmond J., Haggart D. R., Crowther, Daniel, D. R. Haggart, Lee, C.M., Lee, Clare M., Mudaliar Manikhandan A. V., J Keith Vass, Higham Desmond J., Wolf, C.R., Higham, D.J., Wolf C. Roland, Miele Gino, Mudaliar, Manikhandan A. V., Miele, Geno, Desmond J Higham, Clare M Lee, C. Roland Wolf, Miele, G., Manikhandan A. V. Mudaliar, C Roland Wolf, Crowther Daniel, Vass, J.K., Miele, Gino, J. Keith Vass, Crowther, D., Crowther, Daniel; id_orcid, Daniel Crowther, Vass, J. Keith, Desmond J. Higham, Haggart, D.R., Wolf, C. Roland, Lee, Clare   +44 more
core   +1 more source

The CompTox Chemistry Dashboard: a community data resource for environmental chemistry

Journal of Cheminformatics, 2017
Despite an abundance of online databases providing access to chemical data, there is increasing demand for high-quality, structure-curated, open data to meet the various needs of the environmental sciences and computational toxicology communities.
Antony J. Williams, Christopher M. Grulke, Jeff Edwards, Andrew D. McEachran, Kamel Mansouri, Nancy C. Baker, Grace Patlewicz, Imran Shah, John F. Wambaugh, Richard S. Judson, Ann M. Richard   +10 more
doaj   +1 more source

In silico toxicology: An overview of toxicity databases, prediction methodologies, and expert review

, 2022
S.209-242Understanding chemical toxicity is a necessary part of the R&D and regulatory approval process across many industries (e.g. pharmaceuticals, cosmetics, and pesticides).
Escher, Sylvia E., Bower, D., Quigley, D.P., Myatt, Glenn J., Cross, K.P.   +4 more
core   +1 more source

Male fathead minnow transcriptomes and associated chemical analytes in the Milwaukee estuary system

Scientific Data, 2022
Measurement(s) transcripts • water chemistry Technology Type(s) RNAseq • GC/MS Factor Type(s) exposure Sample Characteristic - Organism Pimephales promelas Sample Characteristic - Environment estuary system Sample Characteristic - Location Milwaukee, WI,
Natàlia Garcia-Reyero, Mark A. Arick, E. Alice Woolard, Mitchell Wilbanks, John E. Mylroie, Kathleen Jensen, Michael Kahl, David Feifarek, Shane Poole, Eric Randolph, Jenna Cavallin, Brett R. Blackwell, Daniel Villeneuve, Gerald T. Ankley, Edward J. Perkins   +14 more
doaj   +1 more source

Optimization of Human Neural Progenitor Cells for an Imaging-Based High-Throughput Phenotypic Profiling Assay for Developmental Neurotoxicity Screening

Frontiers in Toxicology, 2022
Studies in in vivo rodent models have been the accepted approach by regulatory agencies to evaluate potential developmental neurotoxicity (DNT) of chemicals for decades. These studies, however, are inefficient and cannot meet the demand for the thousands
Megan Culbreth, Johanna Nyffeler, Johanna Nyffeler, Clinton Willis, Joshua A. Harrill   +4 more
doaj   +1 more source

Leveraging a High-Throughput Screening Method to Identify Mechanisms of Individual Susceptibility Differences in a Genetically Diverse Zebrafish Model

Frontiers in Toxicology, 2022
Understanding the mechanisms behind chemical susceptibility differences is key to protecting sensitive populations. However, elucidating gene-environment interactions (GxE) presents a daunting challenge.
Dylan J. Wallis, Jane La Du, Preethi Thunga, Daniel Elson, Lisa Truong, Siva K. Kolluri, Robyn L. Tanguay, David M. Reif   +7 more
doaj   +1 more source

Integrative network and computational toxicology reveal the molecular mechanisms in PFOA-induced spermatogenic disorder.

Journal of Environmental Management
Perfluorooctanoic acid (PFOA), a widely used industrial chemical, poses significant environmental and biological toxicity, particularly affecting reproductive health.
Yujia Luo, Erfei Xue, Yixiang Zhao, Huimin Lu, Di Xiang, Yuanyuan Zhou, Junfeng Zhan, Zhean Li, Fei Sun   +8 more
semanticscholar   +1 more source