Navigating the Minefield of Computational Toxicology and Informatics: Looking Back and Charting a New Horizon [PDF]
Frontiers in Toxicology, 2020 Grace Patlewicz, Patlewicz Grace
exaly +2 more sources
Current Knowledge on the Use of Computational Toxicology in Hazard Assessment of Metallic Engineered Nanomaterials [PDF]
International Journal of Molecular Sciences, 2017 Guangchao Chen +2 more
exaly +2 more sources
Aggregating Data for Computational Toxicology Applications: The U.S. Environmental Protection Agency (EPA) Aggregated Computational Toxicology Resource (ACToR) System [PDF]
International Journal of Molecular Sciences, 2012 David Reif +2 more
exaly +2 more sources
Predicting molecular initiating events using chemical target annotations and gene expression
BioData Mining, 2022 Background The advent of high-throughput transcriptomic screening technologies has resulted in a wealth of publicly available gene expression data associated with chemical treatments.
Joseph L. Bundy +5 more
doaj +1 more source
A harmonized chemical monitoring database for support of exposure assessments
Scientific Data, 2022 Measurement(s) occurrence of chemicals in environmental and biological media Technology Type(s) mass spectrometry (curation of public data) Sample Characteristic - Organism Homo sapiens • aquatic invertebrates • aquatic vertebrates/mammals • birds • fish
Kristin K. Isaacs +12 more
doaj +1 more source
Annotation depth confounds direct comparison of gene expression across species
BMC Bioinformatics, 2021 Background Comparisons of the molecular framework among organisms can be done on both structural and functional levels. One of the most common top-down approaches for functional comparisons is RNA sequencing. This estimation of organismal transcriptional
Elias Oziolor, Seda Arat, Matthew Martin
doaj +1 more source
Frontiers in Pharmacology, 2022 Current computational technologies hold promise for prioritizing the testing of the thousands of chemicals in commerce. Here, a case study is presented demonstrating comparative risk-prioritization approaches based on the ratio of surrogate hazard and ...
Chantel I. Nicolas +10 more
doaj +1 more source
Artificial intelligence as the new frontier in chemical risk assessment
Frontiers in Artificial Intelligence, 2023 The rapid progress of AI impacts various areas of life, including toxicology, and promises a major role for AI in future risk assessments. Toxicology has shifted from a purely empirical science focused on observing chemical exposure outcomes to a data ...
Thomas Hartung, Thomas Hartung
doaj +1 more source
Toxics, 2022 With the abundance of chemicals in the environment that could potentially cause neurodevelopmental deficits, there is a need for rapid testing and chemical screening assays.
Kimberly A. Jarema +6 more
doaj +1 more source
Proteomics for systems toxicology
Computational and Structural Biotechnology Journal, 2014 Current toxicology studies frequently lack measurements at molecular resolution to enable a more mechanism-based and predictive toxicological assessment.
Bjoern Titz +7 more
doaj +1 more source