Results 71 to 80 of about 721,084 (255)
Editorial: Next generation chemical risk assessment: integration of advances in toxicology, biology and computation [PDF]
Frontiers in ToxicologyKan Shao +3 more
doaj +2 more sources
A Combined In Vitro/In Silico Approach to Identifying Off-Target Receptor Toxicity
iScience, 2018 Summary: Many xenobiotics can bind to off-target receptors and cause toxicity via the dysregulation of downstream transcription factors. Identification of subsequent off-target toxicity in these chemicals has often required extensive chemical testing in ...
Joseph Leedale +9 more
doaj
Predicting toxicity of chemicals: software beats animal testing
EFSA Journal, 2019 We created earlier a large machine‐readable database of 10,000 chemicals and 800,000 associated studies by natural language processing of the public parts of Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) registrations until
Thomas Hartung
doaj +1 more source
Molecules, 2022 Nowadays, increasing interest has recently been given to the exploration of new food preservatives to avoid foodborne outbreaks or food spoilage. Likewise, new compounds that substitute the commonly used synthetic food preservatives are required to ...
Sarra Akermi +9 more
doaj +1 more source
Varieties of Exploratory Experimentation in Nanotoxicology [PDF]
, 2008 There has been relatively little effort to provide a systematic overview of different forms of exploratory experimentation (EE). The present paper examines the growing subdiscipline of nanotoxicology and suggests that it illustrates at least four ways ...
Elliott, Kevin
core
Cell transformation assays for prediction of carcinogenic potential: State of the science and future research needs [PDF]
, 2011 Copyright @ 2011 The Authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use ...
A. D. Scott +65 more
core +2 more sources
Frontiers in Pharmacology, 2016 The Human Toxome Project is part of a long-term vision to modernize toxicity testing for the 21st century. In the initial phase of the project, a consortium of six academic, commercial, and government organizations has partnered to map pathways of ...
Rick A Fasani +10 more
doaj +1 more source
A computational model of the hypothalamic - pituitary - gonadal axis in female fathead minnows (Pimephales promelas) exposed to 17α-ethynylestradiol and 17β-trenbolone [PDF]
, 2011 © 2011 Li et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and ...
Ankley, GT +12 more
core +6 more sources
Frontiers in Pharmacology, 2018 In silico methods are increasingly being used for assessing the chemical safety of substances, as a part of integrated approaches involving in vitro and in vivo experiments.
Manuel Pastor +2 more
doaj +1 more source
Censoring chemical data to mitigate dual use risk [PDF]
arXiv, 2023 The dual use of machine learning applications, where models can be used for both beneficial and malicious purposes, presents a significant challenge. This has recently become a particular concern in chemistry, where chemical datasets containing sensitive labels (e.g.
arxiv