Results 71 to 80 of about 2,598,515 (356)

A Similarity Based Approach for Chemical Category Classification [PDF]

, 2005
This report aims to describe the main outcomes of an IHCP Exploratory Research Project carried out during 2005 by the European Chemicals Bureau (Computational Toxicology Action).
GALLEGOS SALINER Ana, TIER GRACE, WORTH ANDREW   +2 more
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DNA damage and repair proteins in cellular response to sulfur mustard in Iranian veterans more than two decades after exposure [PDF]

, 2018
Delayed effects of sulfur mustard (SM) exposure on the levels of five important damage/repair proteins were investigated in 40 SM-exposed veterans of Iran-Iraq war and 35 unexposed controls.
Balali-Mood, Mahdi, Behravan, Effat, Blain, Peter, Jowsey, Paul, Khateri, Shahriar, Sadeghi, Mahmood, Soroush, Mohammad Reza, Williams, Faith   +7 more
core   +2 more sources

Vertical Membrane‐Free Organ‐on‐a‐Chip for High‐Throughput In Vitro Studies and Drug Screening

Advanced Materials Technologies, EarlyView.
This novel microfluidic organ‐on‐a‐chip (OoC) platform enables cost‐effective, high‐throughput in vitro modeling. With vertical compartmentalization and gravity‐driven flow, it eliminates porous membranes and external pumps. Successfully generating intestine, cartilage, and tendon models, this study demonstrates drug responses, including 5‐fluorouracil
Xavier Barceló, Pooya Azizian, Blanca del Pozo, Marta Olle‐Monge, Lourdes Gombau, Joan M. Cabot   +5 more
wiley   +1 more source

Modeling drug- and chemical- induced hepatotoxicity with systems biology approaches

Frontiers in Physiology, 2012
We provide an overview of computational systems biology approaches as applied to the study of chemical- and drug-induced toxicity. The concept of ‘toxicity pathways’ is described in the context of the 2007 US National Academies of Science report ...
Sudin eBhattacharya, Lisl K.M. Shoda, Qiang eZhang, Courtney eWoods, Brett A. Howell, Scott Q. Siler, Jeffrey L. Woodhead, Yuching eYang, Patrick eMcMullen, Paul B. Watkins, Melvin E. Andersen   +10 more
doaj   +1 more source

A High‐Throughput AngioPlate Platform with Integrated AngioTEER for Modeling and Monitoring Renal Proximal Tubule Injury

Advanced Materials Technologies, EarlyView.
Renal tubular injury is a major contributor to kidney disease, yet remains poorly understood due to the lack of predictive models. This study presents a high‐throughput 3D renal proximal tubule model on the AngioPlate platform integrated with automated TEER measurements (AngioTEER), enabling real‐time monitoring of drug‐induced nephrotoxicity ...
Shravanthi Rajasekar, Anushree Chakravarty, Kimia Asadi Jozani, Brenda Truong, Matana Hendrickson, Ahmed Attia, Muna Sabouny, Anna Basatskaya, Sergi Clotet‐Freixas, Madeleine Ludlow, Alexander Sotra, Dawn S. Y. Lin, Feng Zhang, Boyang Zhang   +13 more
wiley   +1 more source

Agent-based modeling: a systematic assessment of use cases and requirements for enhancing pharmaceutical research and development productivity. [PDF]

, 2013
A crisis continues to brew within the pharmaceutical research and development (R&D) enterprise: productivity continues declining as costs rise, despite ongoing, often dramatic scientific and technical advances. To reverse this trend, we offer various
Hunt, C. Anthony, Hunt, CA, Kennedy, RC, Kim, SHJ, Ropella, GEP   +4 more
core   +2 more sources

HARMLESS Early Warning System for Advanced Materials

Advanced Sustainable Systems, EarlyView.
The HARMLESS Early Warning System tackles Advanced Materials (AdMa) risk governance by providing a framework, organised in two tiers, underpinned with methods/tools to support risk assessors in the pre‐assessment preceding risk assessment. It allows for initial screening to identify AdMa with concerns considering exposure, hazards, sustainability and ...
Julia Prinz, Gregor Nagel, Susan Dekkers, Eugene P. van Someren, Véronique Adam, Veronica Di Battista, Blanca Suarez‐Merino, Wendel Wohlleben, Michael Persson, Anders Baun, Otmar Schmid, Andrea Haase   +11 more
wiley   +1 more source

Using Zebrafish to Screen Developmental Toxicity of Per- and Polyfluoroalkyl Substances (PFAS)

Toxics
Per- and polyfluoroalkyl substances (PFAS) are found in many consumer and industrial products. While some PFAS, notably perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS), are developmentally toxic in mammals, the vast majority of PFAS
Katy N. Britton, Richard S. Judson, Bridgett N. Hill, Kimberly A. Jarema, Jeanene K. Olin, Bridget R. Knapp, Morgan Lowery, Madison Feshuk, Jason Brown, Stephanie Padilla   +9 more
doaj   +1 more source

Modeling and insights into the structural characteristics of drug-induced autoimmune diseases

Frontiers in Immunology, 2022
The incidence and complexity of drug-induced autoimmune diseases (DIAD) have been on the rise in recent years, which may lead to serious or fatal consequences. Besides, many environmental and industrial chemicals can also cause DIAD.
Huizhu Guo, Peitao Zhang, Ruiqiu Zhang, Yuqing Hua, Pei Zhang, Xueyan Cui, Xin Huang, Xiao Li, Xiao Li   +8 more
doaj   +1 more source

Varieties of Exploratory Experimentation in Nanotoxicology [PDF]

, 2008
There has been relatively little effort to provide a systematic overview of different forms of exploratory experimentation (EE). The present paper examines the growing subdiscipline of nanotoxicology and suggests that it illustrates at least four ways ...
Elliott, Kevin
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