Results 71 to 80 of about 73,306 (292)
Advanced Science, EarlyView.ABSTRACT The rising incidence of chronic diseases globally has drawn widespread attention to phytochemicals, which exert targeted preventive and alleviating effect by modulating gut microbiota; thus, a potential strategy for precision nutritional interventions is offered.
Shiqi Bai +6 more
wiley +1 more source
Network toxicology and its application in studying exogenous chemical toxicity
环境与职业医学With the continuous development of society, a large number of new chemicals are continuously emerging, which presents a challenge to current risk assessment and safety management of chemicals.
Yanli LIN +6 more
doaj +1 more source
Advanced Science, EarlyView.Utilizing molecular engineering for network design, three pesticide‐loaded organogels (PLOs) carriers exhibiting varying degrees of flexibility were prepared. The mechanical properties of these carriers, tunable via their network molecular structures, enhance their structural adaptability and retention stability at biological interfaces, thereby ...
Yue Wang +6 more
wiley +1 more source
Advanced Science, EarlyView.CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu +13 more
wiley +1 more source
Progress in computational toxicology
Journal of Pharmacological and Toxicological Methods, 2014 A poster in the ToxI division at the ACS held in SF ...
openaire +2 more sources
HD Physiology Project-Japanese efforts to promote multilevel integrative systems biology and physiome research. [PDF]
, 2017 The HD Physiology Project is a Japanese research consortium that aimed to develop methods and a computational platform in which physiological and pathological information can be described in high-level definitions across multiple scales of time and size.
for HD physiology project investigators +3 more
core
Multimodal Cross‐Attentive Graph‐Based Framework for Predicting In Vivo Endocrine Disruptors
Advanced Science, EarlyView.A multimodal cross‐attentive graph neural network integrates molecular graphs with androgen and estrogen adverse outcome pathway (AOP)–anchored in vitro assay signals to predict in vivo endocrine disruption. By fusing information on Tier‐1 AOP logits with chemical structures, the framework achieves high accuracy and provides assay‐traceable ...
Eder Soares de Almeida Santos +6 more
wiley +1 more source
Modeling drug- and chemical- induced hepatotoxicity with systems biology approaches
Frontiers in Physiology, 2012 We provide an overview of computational systems biology approaches as applied to the study of chemical- and drug-induced toxicity. The concept of ‘toxicity pathways’ is described in the context of the 2007 US National Academies of Science report ...
Sudin eBhattacharya +10 more
doaj +1 more source
Applications of population approaches in toxicology [PDF]
, 2000 International audienceMany experimental or observational studies in toxicology are best analysed in a population framework. Recent examples include investigations of the extent and origin of intra-individual variability in toxicity studies, incorporation
Bois, Frédéric Y.
core +5 more sources
Therapeutic Gases in Biomedicine: Updates on Nitric Oxide and Beyond
Advanced Science, EarlyView.Therapeutic gases, including NO, CO, H2S, H2, CO2, O2, and Xe, play vital roles in cellular signaling and repair. This review highlights the emerging carriers and delivery systems that enable controlled, localized gas release for diagnostic and therapeutic applications.
Syed Muntazir Andrabi +4 more
wiley +1 more source