Results 71 to 80 of about 69,485 (336)

Optimized Monothiol Thioredoxin Derivative (ORP100S) Protects In Vitro and In Vivo from Radiation and Chemotoxicity Without Promoting Tumor Proliferation

Advanced Science, EarlyView.
Native thioredoxin‐1 (TRX) stimulates proliferation and rescues stem cells and cancer cells from multiple stressors by suppressing p53 and inhibiting ferroptosis via GPX4/SLC7A11 upregulation mediated by enhanced KLF4 expression and p53 promoter binding.
Jian Wu, Xiaobei Wang, Parker Mathews, Shaima Jabbar, Min Zhang, Haim Moskowitz, Wei Duan, David P. Nichols, George William Schaaf, John D. Olson, Andrew N. Macintyre, J. Daniel Bourland, Ivan Spasojevic, Jen‐Tsan Ashley Chi, Joel Ross, Nelson Chao, J. Mark Cline, Peter B. Heifetz, Yubin Kang   +18 more
wiley   +1 more source

Adaptive Machine Learning for Electronic Nose‐Based Forensic VOC Classification

Advanced Science, EarlyView.
A 32‐element electronic nose enhanced with machine learning demonstrates exceptional accuracy in differentiating between living and deceased individuals (98.1%), discriminating human and animal specimens (97.2%), and estimating postmortem intervals.
Ivan Shtepliuk, Kerstin Montelius, Jens Eriksson, Donatella Puglisi   +3 more
wiley   +1 more source

An assessment of organic solvent based equilibrium partitioning methods for predicting the bioconcentration behavior of perfluorinated sulfonic acids, carboxylic acids, and sulfonamides [PDF]

, 2009
SPARC, KOWWIN, and ALOGPS octanol-water partitioning (log K~ow~) and distribution (log D) constants were calculated for all C~1~ through C~8~ and the straight chain C~9~ through C~15~ perfluoroalkyl sulfonic acids (PFSAs) and carboxylic acids (PFCAs ...
Kaya Forest, Sierra Rayne
core   +1 more source

Discovering Uncharted Binding Pockets on E3 Ligases Leads to the Identification of FBW7 Allosteric Modulators

Advanced Science, EarlyView.
A computational approach to identify and characterize ligandable binding pockets on E3 ligases is presented. As a validation case, the first low‐micromolar small moleculesthat bind to the FBW7 E3 ligase are identified and confirmed to bind at the intended site.
Míriam Martínez‐Cartró, Álvaro Serrano‐Morrás, Andrea Bertran‐Mostazo, Roger Castaño‐Muñiz, Salvatore Scaffidi, Varbina Ivanova, Noémi Csorba, József Simon, Péter Ábrányi‐Balogh, Yunfeng Li, György M. Keserü, Bing Hao, Xavier Barril, Carles Galdeano   +13 more
wiley   +1 more source

Computational Toxicology [PDF]

Chemical Research in Toxicology, 2020
Nicole C. Kleinstreuer, Weida Tong, Igor V. Tetko   +2 more
openaire   +2 more sources

Recent Advances of Microcapsule‐based Intelligent Coatings: From Bioinspired Designs, Material Selections, to Potential Applications

Advanced Science, EarlyView.
Microcapsule‐based intelligent coatings (MICs) have shown great potential in the fields of biomedicine, smart buildings, marine protection, and aerospace. However, they currently face challenges in the integration of coating functions and applications in complex systems.
Yue Zhao, Xiaopeng Cheng, Ran Zhao, Xipeng Li, Jingxin Meng, Shutao Wang   +5 more
wiley   +1 more source

Predicting toxicity of chemicals: software beats animal testing

EFSA Journal, 2019
We created earlier a large machine‐readable database of 10,000 chemicals and 800,000 associated studies by natural language processing of the public parts of Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) registrations until
Thomas Hartung
doaj   +1 more source

Harvesting the Promise of AOPs: An assessment and recommendations [PDF]

, 2018
The Adverse Outcome Pathway (AOP) concept is a knowledge assembly and communication tool to facilitate the transparent translation of mechanistic information into outcomes meaningful to the regulatory assessment of chemicals.
Ankley, Gerald T., Carusi, Annamaria, Davies, Mark R., De Grandis, Giovanni De, Escher, Beate I., Hodges, Geoff, Wheelan, Maurice, Willet, Catherine, Y. Leung, Kenneth M.   +8 more
core   +3 more sources

Multi‐Dimensional Synergistic Engineering for Boosting Nanozyme Catalysis

Advanced Science, EarlyView.
This review systematically analyzes cutting‐edge strategies for boosting nanozyme catalysis through multi‐dimensional synergistic engineering, containing morphology, electronic structure modulation, external stimulation, and machine learning‐aided design.
Yuechun Li, Zhaowen Cui, Chenxin Ji, Cancan Jia, Wentao Zhang, Jianlong Wang, Yizhong Shen   +6 more
wiley   +1 more source

Discriminating Different Classes of Toxicants by Transcript Profiling [PDF]

, 2004
Male rats were treated with various model compounds or the appropriate vehicle controls. Most substances were either well-known hepatotoxicants or showed hepatotoxicity during preclinical testing.
Albertini, Silvio, Boess, Franziska, de Vera, Maria Cristina, Gasser, Rodolfo, Ruepp, Stefan, Steiner, Guido, Suter, Laura   +6 more
core   +2 more sources