Results 51 to 60 of about 1,966,550 (257)

Simulation-based planning of optimal conditions for industrial computed tomography

, 2022
8 S.We present a method to optimise conditions for industrial computed tomography (CT). This optimisation is based on a deterministic simulation. Our algorithm finds task-specific CT equipment settings to achieve optimal exposure parameters by means of ...
Kasperl, S., Schmidt, U., Reisinger, S., Hiller, J., Franz, M.   +4 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Multidetector computed tomography and 2- and 3-dimensional postprocessing in the evaluation of congenital thoracic vascular anomalies.

, 2008
.Objective: We report examples of congenital anomalies of the thoracic vessels studied with multidetector computed tomography (MDCT), with special respect to bidimensional (2D) and 3-dimensional (3D) postprocessing.
DEL BORRELLO M, GRECO, PANTALEO, CLEMENTE A, BERRETTA S, MORRA A   +4 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Prediction of lymph node metastasis in advanced gastric adenocarcinoma based on dual-energy CT radiomics: focus on the features of lymph nodes with a short axis diameter ≥6 mm

Frontiers in Oncology
ObjectiveTo explore the value of the features of lymph nodes (LNs) with a short-axis diameter ≥6 mm in predicting lymph node metastasis (LNM) in advanced gastric adenocarcinoma (GAC) based on dual-energy CT (DECT) radiomics.Materials and methodsData of ...
Yang You, Yan Wang, Xianbo Yu, Fengxiao Gao, Min Li, Yang Li, Xiangming Wang, Litao Jia, Gaofeng Shi, Li Yang   +9 more
doaj   +1 more source

Shearlet-based regularized ROI reconstruction in fan beam computed tomography

, 2015
Region-of-interest (ROI) reconstruction in computed tomography (CT) is a problem receiving increasing attention in the medical imaging community, due to its potential to lower exposure to X-ray radiation and to reduce the scanning time.
Bubba T. , A., Labate, D., BONETTINI, Silvia, Goossens, B., Zanghirati, G.   +4 more
core   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

CT Radiomics Combined With Clinicopathological Features to Predict Invasive Mucinous Adenocarcinoma in Patients With Lung Adenocarcinoma

Technology in Cancer Research & Treatment, 2023
Objective: This study aimed to develop and validate predictive models using clinical parameters, radiomic features, and a combination of both for invasive mucinous adenocarcinoma (IMA) of the lung in patients with lung adenocarcinoma.
Junjie Zhang MD, Ligang Hao MD, Min Li MD, Qian Xu MD, Gaofeng Shi MD   +4 more
doaj   +1 more source

The effectiveness and cost-effectiveness of computed tomography screening for coronary artery disease : systematic review [PDF]

, 2006
Coronary heart disease (CHD) is one of the main causes of mortality and morbidity in the UK and other Western countries. The disease can be asymptomatic until the first event, which may be a fatal myocardial infarction (heart attack).
Black, C. (Corrinda), Cummins, E. (Ewen), N Waugh, L McIntyre, E Cummins, C Black, Walker, S., Hillis, G. S., Waugh, Norman, G Hillis, S Walker, McIntyre, Linda   +11 more
core   +1 more source