Results 61 to 70 of about 1,850,989 (303)

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Quantifying lung growth with CT-derived intrapulmonary vascular volume: a cross-sectional study

BMC Medical Imaging
Background This study aimed to evaluate lung growth by the quantitative assessment of intrapulmonary vascular volume on chest CT images. Methods All 1122 subjects were grouped with a 2-year age span.
Meijuan Shi, Peng Gao, Meng Li, Weili Yang, Nan Yin, Youmin Guo, Cong Shen   +6 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Imprint Cytology Improves Accuracy of Computed Tomography-Guided Percutaneous Transthoracic Needle Biopsy

, 2009
The aim of the present study was to investigate whether imprint cytology can improve the diagnostic accuracy of computed tomography- guided transthoracic core biopsy.
CHANG, YEUN-CHUNG;YU, CHONG-JEN;LEE, WEN-JENG;KUO, SOW-HSONG;HSIAO, CHENG-HSIANG;JAN, I-SHIOW;HU, FU-CHANG;LIU, HON-MAN;CHAN, WING-KAI;YANG, PAN-CHYR, 張允中;余忠仁;李文正;郭壽雄;蕭正祥;詹一秀;胡賦強;廖漢文;陳榮楷;楊泮池   +1 more
core   +1 more source

Intratumoral heterogeneity derived from synthetic MRI for characterization of HER2 subtypes in breast cancer

Frontiers in Oncology
BackgroundThe human epidermal growth factor receptor 2 (HER2) plays a pivotal role in determining both the prognosis and therapeutic strategies for breast cancer patients.
Junjie Zhang, Ligang Hao, Luqi He, Xiaochong Zhang, Leting Su, Fengxiao Gao   +5 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Shearlet-based regularized ROI reconstruction in fan beam computed tomography

, 2015
Region-of-interest (ROI) reconstruction in computed tomography (CT) is a problem receiving increasing attention in the medical imaging community, due to its potential to lower exposure to X-ray radiation and to reduce the scanning time.
Bubba T. , A., Labate, D., BONETTINI, Silvia, Goossens, B., Zanghirati, G.   +4 more
core   +1 more source

Simulation-based planning of optimal conditions for industrial computed tomography

, 2022
8 S.We present a method to optimise conditions for industrial computed tomography (CT). This optimisation is based on a deterministic simulation. Our algorithm finds task-specific CT equipment settings to achieve optimal exposure parameters by means of ...
Kasperl, S., Schmidt, U., Reisinger, S., Hiller, J., Franz, M.   +4 more
core   +1 more source

Lost in the Vaso‐Occlusion: A Patient's Abdominal Pain Returns With a Vengeance

Pediatric Blood &Cancer, EarlyView.
Dunia Hatabah, Martha E. Stewart, Nathan Maassel, James P. Stevens, Claudia R. Morris, Chris A. Rees   +5 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source