Results 71 to 80 of about 1,966,550 (257)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Quantifying lung growth with CT-derived intrapulmonary vascular volume: a cross-sectional study

BMC Medical Imaging
Background This study aimed to evaluate lung growth by the quantitative assessment of intrapulmonary vascular volume on chest CT images. Methods All 1122 subjects were grouped with a 2-year age span.
Meijuan Shi, Peng Gao, Meng Li, Weili Yang, Nan Yin, Youmin Guo, Cong Shen   +6 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Intratumoral heterogeneity derived from synthetic MRI for characterization of HER2 subtypes in breast cancer

Frontiers in Oncology
BackgroundThe human epidermal growth factor receptor 2 (HER2) plays a pivotal role in determining both the prognosis and therapeutic strategies for breast cancer patients.
Junjie Zhang, Ligang Hao, Luqi He, Xiaochong Zhang, Leting Su, Fengxiao Gao   +5 more
doaj   +1 more source

Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up

Molecular Oncology, EarlyView.
This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani, Laura Mariën, Caro De Weerdt, Sanne Wouters, Laure‐Anne Teuwen, Hans Prenen, Katleen Janssens, Timon Vandamme   +7 more
wiley   +1 more source

Renal cell carcinoma complicating long-term dialysis: Computed tomography-guided aspiration cytology

, 1986
The diagnosis of renal cell carcinoma was established by computed tomography-guided aspiration in two small solid lesions occurring in end-stage kidneys.
Yrizarry, Jose M, Nunez, Diego, Morillo, Gaston, Nadji, Mehrdad, Beerman, Richard   +4 more
core   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Fibre and failure characterization in long glass fibre reinforced polypropylene by X-ray computed tomography

Polymer Testing
Long fibre reinforced thermoplastics (LFTs) have become important in recent years, due to outstanding mechanical properties (such as high strength, high stiffness, and excellent impact behaviour).
Julia Maurer, Dietmar Salaberger, Michael Jerabek, Bernhard Fröhler, Johann Kastner, Zoltán Major   +5 more
doaj   +1 more source

Relationships between lamb carcass quality traits measured by X-ray computed tomography (CT) and current UK-hill sheep breeding goals. [PDF]

, 2008
Genetic parameters were estimated between current UK hill sheep breeding goals and lamb carcass composition and muscularity traits derived using X-ray computed tomography (CT).
McLean, KA, McLaren, A., Lambe, NR; id_orcid, Bishop, S. C., Simm, Geoff, Lambe, N. R., Bünger, L., McLean, K. A., Conington, JE; id_orcid, McLaren, A; id_orcid, Bishop, SC, Simm, G, Bunger, L, Conington, J.   +13 more
core  

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source