Results 101 to 110 of about 12,080,983 (297)

Designing 'action trigger' for architecture modelling design within immersive virtual reality

24th International Conference of the Association for Computer-Aided Architectural Design Research in Asia (CAADRIA 2019), April 15th-18th 2019, Faculty of Architecture & Design, Victoria University of Wellington, Wellington, New Zealand202505 bcchVersion
Yu, H, Lo, TT, Xiao, Z
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Computer-aided vaccine design /

Computational pre-screening of antigens is now routinely applied to the discovery of vaccine candidates. Computer-aided vaccine design is a comprehensive introduction to this exciting field of study.
Ranganathan, Shoba,author., Chuan, Tong Joo,author.   +1 more
core  

A comprehensive study of ground-roasted coffee beans from Coffea liberica as dipeptidyl peptidase IV inhibitors

European Pharmaceutical Journal
Type 2 diabetes mellitus (T2DM), a degenerative disease characterized by insulin resistance, has been reported as a serious healthcare problem, especially in low-to-middle-income countries.
Riswanto Florentinus Dika Octa, Adventra Nicolaus De Deo, Priyambodo Gregorius Seno, Kusraynaldi Titus Marcel, Br Sembiring Angel Yemima Srininta, Larasati Theresia Niken, Windarsih Anjar, Wira Waskitha Stephanus Satria, Gani Michael Raharja, Istyastono Enade Perdana   +9 more
doaj   +1 more source

Spiking Neuron with Sensing Coil Based on a Volatile Memristor

Sensors
The convergence of sensing and processing is a critical frontier in the development of energy-efficient spiking edge intelligence. This paper presents a novel hardware implementation of a sensory neuron evolving from the leaky integrate-and-fire (LIF ...
Timur Karimov, Vyacheslav Rybin, Vasiliy Pchelko, Alexander Mikhailov, Yulia Bobrova, Denis Butusov   +5 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Computer-aided design for rural water supply [PDF]

, 1996
Computer-aided design for rural water ...
Ashok Rao (4914766), B.G. Sangameshwara (7222160), T.P. Halappa Gowda (7222163)   +2 more
core   +2 more sources

Decision Support System for Wind Farm Maintenance Using Robotic Agents

Applied System Innovation
The automation of wind turbine maintenance processes is aimed at improving the operational efficiency of wind farms through timely diagnosis of technical condition, predictive identification of potential failures, and optimization of the distribution of ...
Vladimir Kureichik, Vladislav Danilchenko, Philip Bulyga, Oleg Kartashov   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source