Results 81 to 90 of about 81,688 (266)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

A comprehensive study of ground-roasted coffee beans from Coffea liberica as dipeptidyl peptidase IV inhibitors

European Pharmaceutical Journal
Type 2 diabetes mellitus (T2DM), a degenerative disease characterized by insulin resistance, has been reported as a serious healthcare problem, especially in low-to-middle-income countries.
Riswanto Florentinus Dika Octa, Adventra Nicolaus De Deo, Priyambodo Gregorius Seno, Kusraynaldi Titus Marcel, Br Sembiring Angel Yemima Srininta, Larasati Theresia Niken, Windarsih Anjar, Wira Waskitha Stephanus Satria, Gani Michael Raharja, Istyastono Enade Perdana   +9 more
doaj   +1 more source

Decision Support System for Wind Farm Maintenance Using Robotic Agents

Applied System Innovation
The automation of wind turbine maintenance processes is aimed at improving the operational efficiency of wind farms through timely diagnosis of technical condition, predictive identification of potential failures, and optimization of the distribution of ...
Vladimir Kureichik, Vladislav Danilchenko, Philip Bulyga, Oleg Kartashov   +3 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Assessing How CBCT Image Quality Influences Diagnostic Evaluability of Periodontal Bone: Establishing Human Baselines for AI Training (In Vitro Study)

Oral
Background: Cone-beam computed tomography (CBCT) is increasingly applied for the assessment of periodontal bone levels. However, its measurement reliability and consistency depend strongly on image quality parameters such as voxel size, noise, and ...
Michael Moncher, Vera Zimprich, Jonathan von See, Jörg Philipp Tchorz, Theodor von See, Constantin von See   +5 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Grid-based climate variability analysis of Addis Ababa, Ethiopia

Heliyon
Climate change is an intricate global environmental concern. However, its impact is more pervasive in developing nations such as Ethiopia. Hence, this manuscript examines temperature variability and the magnitude of change over 38 years in the specific ...
Esubalew Nebebe Mekonnen, Aramde Fetene, Ephrem Gebremariam   +2 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source