Results 71 to 80 of about 12,080,983 (297)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

A Hybrid Method for Semantic Cache Analysis of Computational Kernels in C Programs

Applied System Innovation
The performance of modern high-performance computing systems is increasingly constrained not by computational power, but by the efficiency of memory subsystem interaction.
Vitaly Egunov, Alla G. Kravets, Pavel Kravchenya, Anna Matokhina, Vladimir Shabalovsky   +4 more
doaj   +1 more source

ReactionCode: format for reaction searching, analysis, classification, transform, and encoding/decoding

Journal of Cheminformatics, 2020
In the past two decades a lot of different formats for molecules and reactions have been created. These formats were mostly developed for the purposes of identifiers, representation, classification, analysis and data exchange.
Victorien Delannée, Marc C. Nicklaus
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Small Molecule Targeting of Protein–Protein Interactions through Allosteric Modulation of Dynamics

Molecules, 2015
The protein–protein interaction (PPI) target class is particularly challenging, but offers potential for “first in class” therapies. Most known PPI small molecules are orthosteric inhibitors but many PPI sites may be fundamentally intractable to this ...
Benjamin P. Cossins, Alastair D. G. Lawson   +1 more
doaj   +1 more source

Semi-Implicit Multistep Extrapolation ODE Solvers

Mathematics, 2020
Multistep methods for the numerical solution of ordinary differential equations are an important class of applied mathematical techniques. This paper is motivated by recently reported advances in semi-implicit numerical integration methods, multistep and
Denis Butusov, Aleksandra Tutueva, Petr Fedoseev, Artem Terentev, Artur Karimov   +4 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Rethinking Computer-Aided Architectural Design (CAAD) – From Generative Algorithms and Architectural Intelligence to Environmental Design and Ambient Intelligence

, 2022
Computer-Aided Architectural Design (CAAD) finds its historical precedents in technological enthusiasm for generative algorithms and architectural intelligence.
Paul Sanders, Frid, Emma,, Emma Frid, Todor Stojanovski, Peters, Christopher,, Lefosse, Deborah,, Ivor Samuels, Samuels, Ivor,, Partanen, Jenni,, Stojanovski, Todor,, Chhatre, Kiran,, Kiran Chhatre, Jenni Partanen, Deborah Lefosse, Christopher Peters, Zhang, Hui,, Sanders, Paul,, Hui Zhang   +17 more
core   +1 more source