Results 61 to 70 of about 11,465,696 (296)

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Transformer-accelerated discovery of inhibitors targeting the RpsAΔ438 deletion in PZA-resistant tuberculosis

Journal of Cheminformatics
Tuberculosis is a major global public health problem caused by Mycobacterium tuberculosis. Pyrazinamide (PZA), a key first-line drug, is activated to pyrazinoic acid, which inhibits Mycobacterium tuberculosis by targeting ribosomal protein S1 (RpsA) and ...
Jiazhuo Xiao, Muhammad Shahab, Haoke Zhang, Zunnan Huang   +3 more
doaj   +1 more source

Simulation and Analysis of the Second-Order Memristive System in the CUDAynamics Suite

Algorithms
Cycle-to-cycle variability of switching parameters inherent to memristive devices introduces significant problems in the design of neuromorphic systems and non-volatile memory.
Alexander Khanov, Maksim Gozhan, Denis Butusov, Yulia Bobrova, Valerii Ostrovskii   +4 more
doaj   +1 more source

Computer aided design, computer aided manufacture and other computer aids in prosthetics and orthotics [PDF]

Prosthetics & Orthotics International, 1985
(1985). Computer aided design, computer aided manufacture and other computer aids in prosthetics and orthotics. Prosthetics and Orthotics International: Vol. 9, No. 1, pp. 3-11.
openaire   +2 more sources

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Aligned and realistic latent diffusion for text-to-motion generation

Visual Computing for Industry, Biomedicine, and Art
Text-to-motion generation aims to synthesize semantically consistent and naturally coherent motion sequences from natural language descriptions. Given the continuous nature of human motion, diffusion models operating in a continuous latent space offer ...
Zhaowu Li, Rui Liu, Deheng Zhu, Dongsheng Zhou, Xiaopeng Wei   +4 more
doaj   +1 more source

ReactionCode: format for reaction searching, analysis, classification, transform, and encoding/decoding

Journal of Cheminformatics, 2020
In the past two decades a lot of different formats for molecules and reactions have been created. These formats were mostly developed for the purposes of identifiers, representation, classification, analysis and data exchange.
Victorien Delannée, Marc C. Nicklaus
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Small Molecule Targeting of Protein–Protein Interactions through Allosteric Modulation of Dynamics

Molecules, 2015
The protein–protein interaction (PPI) target class is particularly challenging, but offers potential for “first in class” therapies. Most known PPI small molecules are orthosteric inhibitors but many PPI sites may be fundamentally intractable to this ...
Benjamin P. Cossins, Alastair D. G. Lawson   +1 more
doaj   +1 more source