Results 41 to 50 of about 620,111 (234)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems publication information [PDF]

, 2020
Rajesh Gupta, Xin Li, Sara Dailey, Tcad Webmaster, Fabrizio Bonani, Saraju Mohanty, Peng Li, Xun Jiao, Gang Qu, Sherief Reda, Luca Benini, Robert Wille, Philip Brisk, Suman Chakraborty, Tsung-Yi Ho, David Atienza, Ayse Coskun, 3d Design, Optimization Zhuo, Puneet Gupta, Yiyu Shi, Niral Jha, Yier Jin, Subhra Rajat, Chakraborty, Yiorgos Makris, Swaroop Ghosh, Ranjan Preeti, Panda, Chengmo Yang, Zili Shao, Jiang Xu, Chia-Lin Yang, Madhu Mutyam, Abdoulaye Gamati, Sharon Xiaobo, Hu, William Hung, Wei Zhang, Zhiru Zhang, Philippe Coussy, Aviral Shrivastava, Peter Beerel, Ming Hsieh, Frank Liu, Diana Marculescu, Li-C Wang, Sicun Gao, Wenjian Yu, Ngai Wong, C Cheng, Eric Keiter, Laleh Behjat, Stephan Held, David Pan, Abhijit Chatterjee, Qiang Xu, J Henkel, Subhashish Mitra, Rolf Drechsler, Jordi Cortadella, Phillip Stanley-Marbell, Maciej Ciesielski, Hao Zheng, Sudeep Pasricha, Luca Carloni, Hai Li, Y Wang, Nicola Nicolici, Anne Gattiker, Alex Orailoglu, Xiaowei Li, Alberto Sangiovanni, Vincentelli The, Harold Buttner Chair, Yervant Zorian, Rob Rutenbar, Sachin Sapatnekar, Sharad Malik   +78 more
openalex   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Modeling and Analysis of Power Processing Systems (MAPPS). Volume 1: Technical report [PDF]

Computer aided design and analysis techniques were applied to power processing equipment. Topics covered include: (1) discrete time domain analysis of switching regulators for performance analysis; (2) design optimization of power converters using ...
Carter, R. A., Chang, R., Lee, F. C., Rahman, S., Wu, C. H., Yu, Y.   +5 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Preface of the special issue on the conference on formal methods in computer aided design 2018 [PDF]

, 2021
Nikolaj Bjørner, Arie Gurfinkel
openalex   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Computer-aided design (CAD) [PDF]

, 2015
Acronimo di Computer-Aided Design (progettazione assistita da elaboratore). È una famiglia di procedure e software di tipo vettoriale, utilizzati per il disegno architettonico e meccanico, per il rilievo di oggetti ed ...
EMPLER, TOMMASO
core