Results 31 to 40 of about 613,456 (310)

Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu, Kaitlin LaGasse, Cory D. Saucier, Kimberly Raymond, Miranda Lauher‐Charest, Lauren Crowder, Beilei Cai, Mary Lisha Paul, Denise Adams   +8 more
wiley   +1 more source

Efficient workflow scheduling using an improved multi-objective memetic algorithm in cloud-edge-end collaborative framework

Scientific Reports
With the rapid advancement of large-scale model technologies, AI agent frameworks built on foundation models have become a central focus of artificial-intelligence research.
Guangzhang Cui, Wei Zhang, Weiwei Xu, Hujun Bao   +3 more
doaj   +1 more source

Identification of the viscoelastic boundary conditions of Euler‐Bernoulli beams using transmissibility

Engineering Reports, 2019
A new method to identify the viscoelastic boundary conditions of Euler‐Bernoulli beams under forced response is here presented. The boundary conditions and transmissibility function with viscoelastic expressions in terms of the Green function are ...
Guandong Qiao, Salam Rahmatalla
doaj   +1 more source

Interactive graphical computer-aided design system [PDF]

, 1975
System is used for design, layout, and modification of large-scale-integrated (LSI) metal-oxide semiconductor (MOS) arrays. System is structured around small computer which provides real-time support for graphics storage display unit with keyboard, slave
Edge, T. M.
core   +1 more source

Hospitalization Through Families’ Eyes: Comparing Inpatient Care Quality for Children With Sickle Cell Disease and Cystic Fibrosis in Canada

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a chronic, inherited hemoglobinopathy that requires frequent hospitalization for disease‐related complications. Canadian data on inpatient care is limited. This study compared caregiver‐reported hospital experiences of children with SCD to those with cystic fibrosis (CF), a chronic, autosomal recessive ...
Hailey M. Zwicker, Kyle Kemp, Perri Tutelman, Sharon H. J. Hou, Paul Fairie, Maria Santana, Gregory M. T. Guilcher, Taryn Fay‐McClymont, Glenda Bendiak, Wendy Pelletier, Nicola Wright, Fiona Schulte   +11 more
wiley   +1 more source

Kinematic Synthesis of Planar Leg Mechanisms Through Large-Scale Dataset Generation, Geometric Filtering, and Optimization

Machines
Walking is one of many basic human motor functions, yet replicating it in robotic systems remains a complex problem. Historically, the design of walking mechanisms has relied on human intuition and iterative refining.
Ray Tang, Zhijie Lyu, Anurag Purwar
doaj   +1 more source

Supporting reinterpretation in computer-aided conceptual design [PDF]

, 2008
This paper presents research that aims to inform the development of computational tools that better support design exploration and idea transformation - key objectives in conceptual design.
AHRC (Funder), Chase, S., EPSRC (Funder), Garner, S., Jowers, I., Lim, S., McKay, A., Prats, M.   +7 more
core  

Time Toxicity in Wilms Tumor: Quantifying the Burden of Healthcare Interaction in the First Year After Diagnosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Wilms tumor (WT) treatment imposes a significant time burden on patients and their families. Time toxicity is a patient‐centered metric that quantifies the burden of healthcare interaction. We sought to define time toxicity in the first year after diagnosis of WT and hypothesized that it would increase as tumor stage and treatment ...
Caleb Q. Ashbrook, Veerain Gupta, Nicholas J. Clark, Vijay Rings, Lauren E. Corona, Douglass B. Clayton, Daniel J. Benedetti   +6 more
wiley   +1 more source

Computer-aided identification of Neisseria gonorrhoeae’s Bacteriophage-Q-beta inhibitors from selected anti-gonorrheal plants

Discover Chemistry
The emergence of multidrug-resistant Neisseria gonorrhoeae has intensified the need for innovative therapeutic strategies. One promising but underexplored target is the Hfq protein, a key regulator in bacterial stress response and pathogenesis.
Badmus Jamiu Damilare, Che Muhammad Khairul-Hisyam Ismail, Blessing O. Awoyemi, Abdullahi Tunde Aborode, Ibukun Faith Michael, Haruna Isiyaku Umar, Omoboyede Victor, Zainab Naeem Abdulsalam, Oluwabusayo Olufunke Awoyomi, Sodiq Fakorede, Ousainou Gomez, Adekunle Adeoye, Olasehinde Omolayo, Isreal Ayobami Onifade, Abdullahi Temitope Jamiu   +14 more
doaj   +1 more source

An overview of cyber attacks on critical cyber-physical systems and government infrastructures

Security and Safety
This study aimed to analyze the nature, scale, and consequences of cyberattacks on critical cyber-physical systems in Ukraine over the past decade, using a methodology based on classifying attacks by type, threat actor (including Russian hacking groups ...
Tovkun Yuliia, Semerenska Viktoriia, Adamov Alexander   +2 more
doaj   +1 more source