Results 11 to 20 of about 81,688 (266)

Design, Synthesis and Biological Evaluation of Brain-Targeted Thiamine Disulfide Prodrugs of Ampakine Compound LCX001

Molecules, 2016
Ampakine compounds have been shown to reverse opiate-induced respiratory depression by activation of amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptors.
Dian Xiao, Fan-Hua Meng, Wei Dai, Zheng Yong, Jin-Qiu Liu, Xin-Bo Zhou, Song Li   +6 more
doaj   +1 more source

Computer-aided antibody design [PDF]

Protein Engineering Design and Selection, 2012
Recent clinical trials using antibodies with low toxicity and high efficiency have raised expectations for the development of next-generation protein therapeutics. However, the process of obtaining therapeutic antibodies remains time consuming and empirical.
Kuroda, Daisuke, Shirai, Hiroki, Jacobson, Matthew P., Nakamura, Haruki   +3 more
openaire   +2 more sources

Reducing the Concepts of Data Science and Machine Learning to Tools for the Bench Chemist

CHIMIA, 2019
Machine Learning and Data Science have enjoyed a renaissance due to the availability of increased computational power and larger data sets. Many questions can be now asked and answered, that previously were beyond our scope.
Richard A. Lewis, Peter Ertl, Nadine Schneider, Nikolaus Stiefl   +3 more
doaj   +1 more source

Calculation of fatigue fracture in structural elements using a multimode damage model [PDF]

MATEC Web of Conferences, 2022
The problem of nucleation and development for the fatigue fracture process in element of aircraft structure is solved using previously developed cyclic damage model.
Nikitin Ilia, Nikitin Alexander, Wang Chong   +2 more
doaj   +1 more source

STTG-net: a Spatio-temporal network for human motion prediction based on transformer and graph convolution network

Visual Computing for Industry, Biomedicine, and Art, 2022
In recent years, human motion prediction has become an active research topic in computer vision. However, owing to the complexity and stochastic nature of human motion, it remains a challenging problem.
Lujing Chen, Rui Liu, Xin Yang, Dongsheng Zhou, Qiang Zhang, Xiaopeng Wei   +5 more
doaj   +1 more source

Determination of critical plane and assessment of fatigue durability for multiaxial cyclic loading and arbitrary shift of phases [PDF]

MATEC Web of Conferences, 2019
An analytical solution for the well-known fatigue criterion proposed by Papadopoulos was obtained. An arbitrary shift of phases was taken into account. Comparison between analytical, numerical solutions with experimental data was made.
Stratula Boris A., Burago Nikolai G., Nikitin Alexander D., Nikitin Ilia S.   +3 more
doaj   +1 more source

VR as a 3D Modelling Tool in Engineering Design Applications

Applied Sciences, 2021
The study aims to explore the usefulness of existing VR 3D modelling tools for use in mechanical engineering. Previous studies have investigated the use of VR 3D modelling tools in conceptual phases of the product development process.
Daria Vlah, Vanja Čok, Uroš Urbas
doaj   +1 more source

Industrial Environmental Impact Assessment Method Based on Detection of Complex Anomalies in Time Series

Applied System Innovation
To minimize the environmental impact of energy enterprises, it is important to promptly identify cases of possible changes in the quality of wastewater generated at power plants, that is, cases of exceeding the maximum permissible concentrations of ...
Elena Safonova, Alla Kravets, Maxim Shcherbakov, Alexey Kizim, Mohammad Al-Gunaid, Alexander Echin   +5 more
doaj   +1 more source

Semantic Analysis of Technical Documentation: Systematic Review, Formal Task Definition, and Transformer-Based NER Implementation

Big Data and Cognitive Computing
The increasing complexity and volume of technical documentation, including requirements specifications, patents, and engineering reports, create significant challenges for manual analysis and knowledge extraction.
Alexander Echin, Alla G. Kravets, Elena Safonova, Dmitry A. Skorobogatchenko, Danila Karasev   +4 more
doaj   +1 more source

Synthesis and Biological Evaluation of Chromenylurea and Chromanylurea Derivatives as Anti-TNF-α agents that Target the p38 MAPK Pathway

Molecules, 2014
A series of 1-aryl-3-(2H-chromen-5-yl)urea and 1-aryl-3-(chroman-5-yl)urea derivatives were designed, synthesized and evaluated for their inhibitory activities towards TNF-α production in lipopolysaccharide-stimulated THP-1 cells.
Xingzhou Li, Xinming Zhou, Jing Zhang, Lili Wang, Long Long, Zhibing Zheng, Song Li, Wu Zhong   +7 more
doaj   +1 more source