Results 111 to 120 of about 1,561,059 (402)

Integrative systems‐level analysis reveals a contextual crosstalk between hypoxia and global metabolism in human breast tumors

Molecular Oncology, EarlyView.
Breast tumor samples scored for metabolic deregulation (M1 to M3) were given a hypoxia score (HS). The highest HS occurred in patients with strongest metabolic deregulation (M3), supporting tumor aggressiveness. HS correlated with the highest number of metabolic pathways in M1. This suggests hypoxia to be an early event in metabolic deregulation.
Raefa Abou Khouzam, Salem Chouaib, Mohammad Askandar Iqbal   +2 more
wiley   +1 more source

Complex System Design with Design Languages: Method, Applications and Design Principles [PDF]

arXiv, 2018
Graph-based design languages in UML (Unified Modeling Language) are presented as a method to encode and automate the complete design process and the final optimization of the product or complex system. A design language consists of a vocabulary (digital building blocks) and a set of rules (digital composition knowledge) along with an executable ...
arxiv  

The accumulation of myeloid‐derived suppressor cells participates in abdominal infection‐induced tumor progression through the PD‐L1/PD‐1 axis

Molecular Oncology, EarlyView.
This study explores how sepsis affects GC progression by creating an immunosuppressive environment. Our findings reveal that sepsis promotes immune dysregulation, enhancing tumor growth and metastasis. Targeting the PD‐1/PD‐L1 pathway with monoclonal antibodies shows potential for restoring immune function and improving outcomes in cancer patients ...
Yiding Wang, Ting Guo, Xiaofang Xing, Xijuan Liu, Xuejun Gan, Yingai Li, Yan Liu, Fei Shan, Zhouqiao Wu, Jiafu Ji, Ziyu Li   +10 more
wiley   +1 more source

Factors modulating 99mTc‐MAA planar lung dosimetry for 90Y radioembolization

Journal of Applied Clinical Medical Physics, Volume 23, Issue 12, December 2022., 2022
Abstract Purpose To investigate the accuracy and biases of predicted lung shunt fraction (LSF) and lung dose (LD) calculations via 99mTc‐macro‐aggregated albumin (99mTc‐MAA) planar imaging for treatment planning of 90Y‐microsphere radioembolization.
Benjamin P. Lopez, Armeen Mahvash, James P. Long, Marnix G. E. H. Lam, S. Cheenu Kappadath   +4 more
wiley   +1 more source

Joint Center Estimation Using Single-Frame Optimization: Part 2: Experimentation

Sensors, 2018
Human motion capture is driven by joint center location estimates, and error in their estimation can be compounded by subsequent kinematic calculations. Soft tissue artifact (STA), the motion of tissue relative to the underlying bones, is a primary cause
Eric Frick, Salam Rahmatalla
doaj   +1 more source

Expanding Biosensing Abilities through Computer-Aided Design of Metabolic Pathways.

ACS Synthetic Biology, 2016
Detection of chemical signals is critical for cells in nature as well as in synthetic biology, where they serve as inputs for designer circuits. Important progress has been made in the design of signal processing circuits triggering complex biological ...
Vincent K Libis, Baudoin Delépine, J. Faulon   +2 more
semanticscholar   +1 more source

Modeling and Analysis of Power Processing Systems (MAPPS). Volume 1: Technical report [PDF]

Computer aided design and analysis techniques were applied to power processing equipment. Topics covered include: (1) discrete time domain analysis of switching regulators for performance analysis; (2) design optimization of power converters using ...
Carter, R. A., Chang, R., Lee, F. C., Rahman, S., Wu, C. H., Yu, Y.   +5 more
core   +1 more source

Computer-aided design (CAD) [PDF]

, 2015
Acronimo di Computer-Aided Design (progettazione assistita da elaboratore). È una famiglia di procedure e software di tipo vettoriale, utilizzati per il disegno architettonico e meccanico, per il rilievo di oggetti ed ...
EMPLER, TOMMASO
core  

NanoCMSer: a consensus molecular subtype stratification tool for fresh‐frozen and paraffin‐embedded colorectal cancer samples

Molecular Oncology, EarlyView.
Consensus molecular subtypes (CMS1‐4) have been identified to study colorectal cancer heterogeneity and serve as potential biomarkers. In this study, we developed and evaluated NanoCMSer, a NanoString‐based classifier using 55 genes, optimized for FF and FFPE to facilitate the clinical evaluation of CMS subtyping.
Arezo Torang, Simone van de Weerd, Veerle Lammers, Sander van Hooff, Inge van den Berg, Saskia van den Bergh, Miriam Koopman, Jan N. IJzermans, Jeanine M. L. Roodhart, Jan Koster, Jan Paul Medema   +10 more
wiley   +1 more source

Feasibility of radical cardiac‐sparing, treatment planning strategies for patients with locally advanced, non‐small cell lung cancer

Journal of Applied Clinical Medical Physics, Volume 23, Issue 12, December 2022., 2022
Abstract Purpose A set of treatment planning strategies were designed and retrospectively implemented for locally advanced, non‐small cell lung cancer (NSCLC) patients in order to minimize cardiac dose without compromising target coverage goals. Methods Retrospective analysis was performed for 20 NSCLC patients prescribed to 60–66 Gy that received a ...
Joshua P. Kim, Jake Dewalt, Aharon Feldman, Khaled Adil, Benjamin Movsas, Indrin J. Chetty   +5 more
wiley   +1 more source