Results 111 to 120 of about 1,430,083 (395)
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Decision Support System for Wind Farm Maintenance Using Robotic Agents
Applied System InnovationThe automation of wind turbine maintenance processes is aimed at improving the operational efficiency of wind farms through timely diagnosis of technical condition, predictive identification of potential failures, and optimization of the distribution of ...
Vladimir Kureichik +3 more
doaj +1 more source
, 1991 Der Arbeitsbericht gibt zunächst einen Überblick über die technisch orientierten rechnergestützten Komponenten im Rahmen des Computer Integrated Manufacturing (CIM), die sogenannten CAx-Systeme oder CA-Systeme: CAD (Computer Aided Design) CAP (Computer ...
Kurbel, Karl
core
Computer Aided Plumbing Design [PDF]
, 2007 This study has been used to eliminate the rigorous activities and time consuming mathematical analysis involved in Plumbing design. The various mathematical steps employed in the design of plumbing systems has been converted into easily interpreted hand ...
Ajayi, Oluseyi. O, Koya, Olufemi. A
core +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Improved Adaptive Routing Algorithm in Distributed Data Centers
Advances in Electrical and Electronic Engineering, 2017 Currently, telecom operators use virtualization of network infrastructure based on Data Centers (DCs). But when a company grows to a certain size and one DC is not sufficient, there are questions how to further develop the network infrastructure.
Dmitry Perepelkin, Maria Ivanchikova
doaj +1 more source
Computer-aided design and analysis of circuits and systems Final report, 20 Sep. 1966 - 1 Jul. 1968 [PDF]
Consolidation, standardization, and qualification of computer program routines associated with computer-aided design and analysis of circuits and ...
Henry, E. W.
core +1 more source
Parametric modelling of Malaysian teeth template using computer aided design [PDF]
, 2016 This study explored a new method and process of design denture using CAD technology to develop a template of a complete denture. Computer aided design were used as a tool of the design process.
ABAS, NOR HASLINDA +4 more
core +4 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source