Results 141 to 150 of about 94,743 (307)

Using computer-aided design/computer-aided manufacturing technology for foreign body removal from soft tissues: a case report. [PDF]

Maxillofac Plast Reconstr Surg
Hoshino T, Yoshida S, Kurihara C, Oiwa K, Tachizawa K, Sugahara K, Katakura A.   +6 more
europepmc   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Computer-Aided Design (CAD) and Computer-Aided Manufacturing (CAM)-Based Fabrication of Andrews Bridge for Comprehensive Rehabilitation of Seibert Class III Ridge Defect: A Case Report. [PDF]

Cureus
Saxena D, Jindal T.
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Predicted IL-18/IL-18R Binding Improvement Through Protein Interface Modification with Computer-Aided Design. [PDF]

Biomolecules
Prompat N, Peeyatu C, Saetang J, Roongsawang N, Sangkhathat S, Tipmanee V.   +5 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Computer-aided design enables repurposing of proprotein convertase subtilisin/kexin type 9 degrader from cholesterol-lowering to colon cancer therapy. [PDF]

Mol Biomed
Fan G, Zha J, Chen S, Cang P, Zhang Q, Yang J, Liu M.   +6 more
europepmc   +1 more source

Application of Computer-Aided Molecular Design to a Pharmaceutical Separation

, 2022
Kaden Hubler, David Rope, Kyle V. Camarda   +2 more
openalex   +2 more sources

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source

Antisense Versus Antigene in the Computer-Aided Design of Triplex-Forming Oligonucleotides (TFO): Insights from a Dual-Method Review, Combining Bibliometric and Systematic Review. [PDF]

Int J Mol Sci
Hincapié-López M, Marín-Alfonso J, Romero-Riaño E, Núñez-Rodríguez RA, Pabón-Martínez YV.   +4 more
europepmc   +1 more source