Results 141 to 150 of about 1,561,059 (402)

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

open access: yesMolecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita   +1 more
wiley   +1 more source

Statistical process control to monitor use of a web‐based autoplanning tool

open access: yesJournal of Applied Clinical Medical Physics, Volume 23, Issue 12, December 2022., 2022
Abstract Purpose To investigate the use of statistical process control (SPC) for quality assurance of an integrated web‐based autoplanning tool, Radiation Planning Assistant (RPA). Methods Automatically generated plans were downloaded and imported into two treatment planning systems (TPSs), RayStation and Eclipse, in which they were recalculated using ...
Hunter Mehrens   +5 more
wiley   +1 more source

Magnetic Flux Sensor Based on Spiking Neurons with Josephson Junctions

open access: yesSensors
Josephson junctions (JJs) are superconductor-based devices used to build highly sensitive magnetic flux sensors called superconducting quantum interference devices (SQUIDs).
Timur Karimov   +5 more
doaj   +1 more source

FEATURES OF THE MANAGEMENT OF DATA ENCRYPTION KEYS IN THE CLOUD STORAGE MS SQL AZURE

open access: yesInformatyka, Automatyka, Pomiary w Gospodarce i Ochronie Środowiska, 2018
The main principles of data security and access organization in the Microsoft Azure cloud storage are considered. A role of hierarchy and access keys are presented.
Olexander Beley
doaj   +1 more source

Analysis of comprehensive genomic profiling of solid tumors with a novel assay for broad analysis in clinical diagnostics

open access: yesMolecular Oncology, EarlyView.
In molecular cancer diagnostics, comprehensive genomic profiling (CGP) is going to replace the small NGS panels since it provides all clinically relevant somatic variants as well as genomic biomarkers with clinical value. Here, we compared two CGP assays and demonstrate that the choice for diagnostic implementation will depend on the specific ...
Guy Froyen   +17 more
wiley   +1 more source

Evaluation of patient doses for routine digital radiography procedures toward establishing an institutional diagnostic reference levels: A case study in Sri Lanka

open access: yesJournal of Applied Clinical Medical Physics, Volume 23, Issue 12, December 2022., 2022
Abstract The present study was conducted as part of a comprehensive work to establish National Diagnostic Reference Levels (NDRLs) in Sri Lanka for the first time. DRLs can be used as an effective optimization tool for identifying unusually high or low patient doses during X‐ray examinations.
Sachith Welarathna   +3 more
wiley   +1 more source

Computer-Aided Drug Design in Epigenetics

open access: yesFrontiers in Chemistry, 2018
Epigenetic dysfunction has been widely implicated in several diseases especially cancers thus highlights the therapeutic potential for chemical interventions in this field.
Wenchao Lu   +4 more
semanticscholar   +1 more source

Geometric modeling for computer-aided design [PDF]

open access: yes
Software was developed to be used with the derivation of smooth three dimensional surfaces from a sequence of cross sections. Problems arising in the creation of surfaces by extrusion are considered and calculated physical properties are ...
Schwing, James L., Spangler, Jan
core   +1 more source

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