Results 161 to 170 of about 613,456 (310)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Computer-Aided Design of <i>Plasmodium chabaudi</i>-Derived Peptides with Dual Antibiofilm and Anti-inflammatory Activities. [PDF]

ACS Med Chem Lett
Quigua Orozco RM, Santos ADO, Rossetto JP, Madalozzo ES, Luchi LV, Rezende SB, Chan LY, Buccini DF, Macedo MLR, Mehta A, Craik DJ, Franco OL, Cardoso MH.   +12 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Revolutionizing dental restorations: Insights into computer-aided design/computer-aided manufacturing materials - A systematic review. [PDF]

Dent Res J (Isfahan)
Ramnarayan BK, Nagral SM, Nanaiah P, Satelur KP, Venkatasubramanian R, Avinash J.   +5 more
europepmc   +1 more source

Computer-aided design of bevel gear tooth surfaces [PDF]

This paper presents a computer-aided design procedure for generating bevel gears. The development is based on examining a perfectly plastic, cone-shaped gear blank rolling over a cutting tooth on a plane crown rack.
Coy, John J., Huston, Ronald L., Shuo, Hung Chang   +2 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Customized positioning of the glenoid component in reverse shoulder arthroplasty: a new computer aided design methodology. [PDF]

Int Orthop
Cirello A, Ingrassia T, Rovere G, Nalbone L, Camarda L, Mirulla IA, Nigrelli V, Ricotta V, Tantillo M.   +8 more
europepmc   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Defining the influence of digitalization on the future of dentistry through an educational handbook for Computer Aided Design tool training. [PDF]

BMC Med Educ
Anghel MA, Marinescu IR, Ionescu AG, Micu D, Iliescu AA, Mărășescu PC, Uriciuc WA, Zaharia C, Petrescu SMS, Diaconu OA, Manolea HO.   +10 more
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source