Threonine 348 regulates the subcellular localization of PTEN
FEBS Open Bio, EarlyView.Thr348 in the C2 domain is a key contributor to PTEN subcellular localization. The PTEN350 fragment and PTENA4 accumulated in the nucleus, whereas PTENK13R,A4 predominantly localized to the plasma membrane. In contrast, substitution of Thr348 with Asp (T348D) disrupted these characteristic localization patterns, resulting in predominant cytoplasmic ...
Takashi Kato, Suzu Tanaka, Miyu Ohashi
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To Evaluate Clinical Performance of Preformed Zirconia Crowns, Computer-aided Design and Computer-aided Manufacturing Zirconia Crowns, and Bioflx Crowns in Primary Molars Postendodontic Therapy. [PDF]
Int J Clin Pediatr DentSolanki R +4 more
europepmc +1 more source
FEBS Open Bio, EarlyView.Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata +3 more
wiley +1 more source
30th International Conference on Computer-Aided Architectural Design Research in Asia (CAADRIA 2025), 22-29 March 2025, The University of Tokyo, JAPAN202505 bcchVersion of RecordOthersPolyU (UGC)PublishedCopyright retained by ...
Lo, TTS, Li, Y, Bao, H, He, Y
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Least Invasive Pectus Excavatum Reconstruction: Case Report of 3-dimensional Computer-aided Design Custom-made Silicone Implant. [PDF]
Plast Reconstr Surg Glob OpenMurr C, Makkawi K, Chavoin JP.
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MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation
FEBS Open Bio, EarlyView.MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima +8 more
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Guided periodontal plastic surgery for the correction of gummy smile using data merging and computer-aided design and computer-aided manufacturing surgical guide. [PDF]
J Indian Soc PeriodontolKerudi LV, Mane VM, Patil AY, Kerudi VV.
europepmc +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
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Long-term stability of ocular function after alloplastic computer-aided design/computer-aided manufacturing reconstruction of posttraumatic orbital defects: a retrospective cohort study. [PDF]
Head Face MedSkade S +8 more
europepmc +1 more source
Aging and Cancer, EarlyView.Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi +3 more
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