Results 191 to 200 of about 1,430,083 (395)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

open access: yesFEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu   +5 more
wiley   +1 more source

Computer Aided Design of Worms in the Same Axis [PDF]

open access: green, 2012
Zsuzsa Balajti, József Ábel
openalex  

Validation of RetroPath, a computer‐aided design tool for metabolic pathway engineering

open access: green, 2014
Tamás Fehér   +7 more
openalex   +2 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

LEA3D: A Computer-Aided Ligand Design for Structure-Based Drug Design

open access: green, 2005
Dominique Douguet   +3 more
openalex   +1 more source

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