Results 71 to 80 of about 593,691 (360)

Exploratory Landscape Validation for Bayesian Optimization Algorithms

Mathematics
Bayesian optimization algorithms are widely used for solving problems with a high computational complexity in terms of objective function evaluation. The efficiency of Bayesian optimization is strongly dependent on the quality of the surrogate models of ...
Taleh Agasiev, Anatoly Karpenko
doaj   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Marginal accuracy of computer-aided design- and computer-aided manufacturing-fabricated full-arch zirconia restoration

Clinical, Cosmetic and Investigational Dentistry, 2018
Niwut Juntavee,1 Issarawas Sirisathit2 1Department of Prosthodontics, 2Division of Biomaterials and Prosthodontics Research, Faculty of Dentistry, Khon Kaen University, Khon Kaen, Thailand Objective: This study evaluated marginal accuracy of full-arch ...
Juntavee N, Sirisathit I
doaj  

Memory Effect in the Spatial Series Based on Diamond and Graphite Crystals

Molecules, 2020
To study the relation between the structure of a compound and its properties is one of the fundamental trends in chemistry and materials science.
Ludmila Grigoreva, Alexander Razdolsky, Vladimir Kazachenko, Nadezhda Strakhova, Veniamin Grigorev   +4 more
doaj   +1 more source

Modeling and Analysis of Power Processing Systems (MAPPS). Volume 1: Technical report [PDF]

Computer aided design and analysis techniques were applied to power processing equipment. Topics covered include: (1) discrete time domain analysis of switching regulators for performance analysis; (2) design optimization of power converters using ...
Carter, R. A., Chang, R., Lee, F. C., Rahman, S., Wu, C. H., Yu, Y.   +5 more
core   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Dual modality prompt learning for visual question-grounded answering in robotic surgery

Visual Computing for Industry, Biomedicine, and Art
With recent advancements in robotic surgery, notable strides have been made in visual question answering (VQA). Existing VQA systems typically generate textual answers to questions but fail to indicate the location of the relevant content within the ...
Yue Zhang, Wanshu Fan, Peixi Peng, Xin Yang, Dongsheng Zhou, Xiaopeng Wei   +5 more
doaj   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Interactive graphical computer-aided design system [PDF]

, 1975
System is used for design, layout, and modification of large-scale-integrated (LSI) metal-oxide semiconductor (MOS) arrays. System is structured around small computer which provides real-time support for graphics storage display unit with keyboard, slave
Edge, T. M.
core   +1 more source

Development of a STEP-compliant design and manufacturing framework for discrete sheet metal bend parts [PDF]

, 2016
Metal sheets have the ability to be formed into nonstandard sizes and sections. Displacement-controlled computer numerical control press brakes are used for three-dimensional sheet metal forming.
Ali, Liaqat, Baqai, Aamer Ahmed, Choudhry, Rizwan Saeed, Faraz, Zahid, Jaffery, Syed Husain Imran, Khan, Mushtaq, Mahmood, Khalid, Tarar, Wasim Akram, Waheed ul Haq, Syed   +8 more
core   +2 more sources