Results 71 to 80 of about 94,743 (307)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Decision Support System for Wind Farm Maintenance Using Robotic Agents

Applied System Innovation
The automation of wind turbine maintenance processes is aimed at improving the operational efficiency of wind farms through timely diagnosis of technical condition, predictive identification of potential failures, and optimization of the distribution of ...
Vladimir Kureichik, Vladislav Danilchenko, Philip Bulyga, Oleg Kartashov   +3 more
doaj   +1 more source

COMPUTER-AIDED DESIGN OF THE VIVALDI ANTENNA FOR ULTRA-WIDEBAND ELECTROMAGNETIC PULSE RADIATION

, 2021
A.I. Mel’nichuk, N. V. Goryachev, N. К. Yurkov   +2 more
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

A comprehensive study of ground-roasted coffee beans from Coffea liberica as dipeptidyl peptidase IV inhibitors

European Pharmaceutical Journal
Type 2 diabetes mellitus (T2DM), a degenerative disease characterized by insulin resistance, has been reported as a serious healthcare problem, especially in low-to-middle-income countries.
Riswanto Florentinus Dika Octa, Adventra Nicolaus De Deo, Priyambodo Gregorius Seno, Kusraynaldi Titus Marcel, Br Sembiring Angel Yemima Srininta, Larasati Theresia Niken, Windarsih Anjar, Wira Waskitha Stephanus Satria, Gani Michael Raharja, Istyastono Enade Perdana   +9 more
doaj   +1 more source

Improved Adaptive Routing Algorithm in Distributed Data Centers

Advances in Electrical and Electronic Engineering, 2017
Currently, telecom operators use virtualization of network infrastructure based on Data Centers (DCs). But when a company grows to a certain size and one DC is not sufficient, there are questions how to further develop the network infrastructure.
Dmitry Perepelkin, Maria Ivanchikova
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Grid-based climate variability analysis of Addis Ababa, Ethiopia

Heliyon
Climate change is an intricate global environmental concern. However, its impact is more pervasive in developing nations such as Ethiopia. Hence, this manuscript examines temperature variability and the magnitude of change over 38 years in the specific ...
Esubalew Nebebe Mekonnen, Aramde Fetene, Ephrem Gebremariam   +2 more
doaj   +1 more source

Biodynamics of supine humans and interaction with transport systems during vibration and shocks

Journal of Low Frequency Noise, Vibration and Active Control, 2019
This work investigates the effect of the contact surfaces on the biomechanical response of supine humans during whole-body vibration and shocks. Twelve participants were exposed to three-dimensional random vibration and shocks and were tested with two ...
Salam Rahmatalla, Jonathan DeShaw, Khalid Barazanji   +2 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source