Results 111 to 120 of about 141,530 (234)

Computer-aided drug design for virtual-screening and active-predicting of main protease (M^pro) inhibitors against SARS-CoV-2. [PDF]

Front Pharmacol, 2023
Dai R, Gao H, Su R.
europepmc   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

Discovery of Highly Potent Noncovalent Inhibitors of SARS-CoV-2 Main Protease through Computer-Aided Drug Design. [PDF]

J Med Chem
Okabe A, Carney DW, Tawada M, Akther T, Aida J, Takagi T, Dougan DR, Leffler AE, Bell JA, Frye L, Hickey ER, Komandla M, Tao W, Selimkhanov J, Yonemori K, Chang E, Saikatendu K, Ochida A.   +17 more
europepmc   +1 more source

Mechanisms of action underlying Shentong Zhuyu decoction based treatment of rheumatoid arthritis using systems biology and computer-aided drug design. [PDF]

Medicine (Baltimore), 2023
Bai S, Han X, Lan Y, Wang H, Wang R, Li L, Song Q, Li A.   +7 more
europepmc   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Chrysin and Luteolin from Moroccan Propolis to Prevent Aggressive Periodontitis Caused by Aggregatibacter actinomycetemcomitans Leukotoxin: A Computer-Aided Drug Design Approach. [PDF]

Pharmaceuticals (Basel)
EL Meskini D, Chraa F, Touhtouh J, Ouadghiri M, Gallo M, Bouyahya A, Aanniz T.   +6 more
europepmc   +1 more source

Key ingredients in Verbena officinalis and determination of their anti-atherosclerotic effect using a computer-aided drug design approach. [PDF]

Front Plant Sci, 2023
Chen Y, Gan Y, Yu J, Ye X, Yu W.
europepmc   +1 more source

A Qualitative Analysis of Patient Perspectives and Preferences in Lupus Management to Guide Lupus Guidelines Development

Arthritis Care &Research, EarlyView.
Objective A patient‐centered approach for chronic disease management, including systemic lupus erythematosus (SLE), aligns treatment with patients’ values and preferences, leading to improved outcomes. This paper summarizes how patient experiences, perspectives, and priorities informed the American College of Rheumatology (ACR) 2024 Lupus Nephritis (LN)
Shivani Garg, Izzy Hartel, Lisa R. Sammaritano, Anca Askanase, Bonnie L. Bermas, Maria Dall'Era, Alí Duarte‐García, Victoria P. Werth, Brad Rovin, Reem A. Mustafa, Amy S. Turner, Bené Williams, Brian L. Ung, Hiya Bhavsar, Monique C. Gore‐Massy, Nahirannette Pulido, Natacha Guerrero, Natalie M. Smith, Wambui Machua, Linda T. Hiraki, Mary Beth Son   +20 more
wiley   +1 more source

Exploring the mechanism of Inula japonica Thunb. against non-small cell lung cancer using a computer-aided drug design approach. [PDF]

Medicine (Baltimore)
Qian H, Wang B, Zhang L, Li J, Huang X, Liu B, Zhao Y, Wang M.   +7 more
europepmc   +1 more source

Computer-aided drug design approaches applied to screen natural product's structural analogs targeting arginase in Leishmania spp. [PDF]

F1000Res, 2023
Barazorda-Ccahuana HL, Goyzueta-Mamani LD, Candia Puma MA, Simões de Freitas C, de Sousa Vieria Tavares G, Pagliara Lage D, Ferraz Coelho EA, Chávez-Fumagalli MA.   +7 more
europepmc   +1 more source