Results 31 to 40 of about 12,983,542 (274)
Correction: Haque et al. Marine Natural Products in Clinical Use. Mar. Drugs 2022, 20, 528
Marine Drugs, 2022 The authors would like to make corrections to a recently published paper [...]
Neshatul Haque +4 more
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Marine Natural Products in Clinical Use
Marine Drugs, 2022 Marine natural products are potent and promising sources of drugs among other natural products of plant, animal, and microbial origin. To date, 20 drugs from marine sources are in clinical use.
Neshatul Haque +4 more
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Synthesis and p38 Inhibitory Activity of Some Novel Substituted N,N′-Diarylurea Derivatives
Molecules, 2016 We have identified a novel series of substituted N,N′-diarylurea p38α inhibitors. The inhibitory activity of the target compounds against the enzyme p38α, MAPKAPK2 in BHK cells, TNF-α release in LPS-stimulated THP-1 cells and p38α binding experiments ...
Dianxi Zhu +4 more
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Proceedings of the 25th Conference on Formal Methods in Computer-Aided Design, FMCAD 2025 [PDF]
The Conference on Formal Methods in Computer-Aided Design (FMCAD) is an annual conference on the theory and applications of formal methods in hardware and system verification.
Formal Methods in Computer Aided Design
core +1 more source
In Silico Methods for Identification of Potential Active Sites of Therapeutic Targets
Molecules, 2022 Target identification is an important step in drug discovery, and computer-aided drug target identification methods are attracting more attention compared with traditional drug target identification methods, which are time-consuming and costly.
Jianbo Liao +3 more
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Changes in Alprazolam Metabolism by CYP3A43 Mutants
Biomedicines, 2022 Alprazolam is a triazolobenzodiazepine which is most commonly used in the short-term management of anxiety disorders, often in combination with antipsychotics. The four human members of the CYP3A subfamily are mainly responsible for its metabolism, which
Jie Zhao +5 more
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Molecules, 2015 A novel series of substituted N,N′-diaryl ureas that act as p38α inhibitors have been designed and synthesized based on two key residues (Gly110 and Thr106) that are different in p38α MAPK than in other kinases.
Dianxi Zhu +3 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Embryonal tumors comprise the majority of malignant central nervous system (CNS) neoplasms diagnosed in children under 3 years of age. Compared with their counterparts in older children, these tumors exhibit distinct molecular biology and a more aggressive clinical phenotype, while their management is complicated by the heightened ...
Sudarshawn Damodharan +3 more
wiley +1 more source
Computer-Aided Drug Design for AMP-Activated Protein Kinase Activators
, 2011 AMP-activated protein kinase (AMPK) is an important therapeutic target for the potential treatment of metabolic disorders, cardiovascular disease and cancer.
Yu, Hui +15 more
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Conformational Heterogeneity of the HIV Envelope Glycan Shield
Scientific Reports, 2017 To better understand the conformational properties of the glycan shield covering the surface of the HIV gp120/gp41 envelope (Env) trimer, and how the glycan shield impacts the accessibility of the underlying protein surface, we performed enhanced ...
Mingjun Yang +4 more
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