Results 41 to 50 of about 12,983,542 (274)

Asymmetric Synthesis and Absolute Configuration Assignment of a New Type of Bedaquiline Analogue

Molecules, 2015
Bedaquiline is the first FDA-approved new chemical entity to fight multidrug-resistant tuberculosis in the last forty years. Our group replaced the quinoline ring with a naphthalene ring, leading to a new type of triarylbutanol skeleton.
Chang-Jiang Qiao, Xiao-Kui Wang, Fei Xie, Wu Zhong, Song Li   +4 more
doaj   +1 more source

Provider and Parent Perspectives on Prioritizing the “Asking and Monitoring” Pediatric Cancer Psychosocial Standards of Care

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background The Standards for Psychosocial Care for Children with Cancer and Their Families (“Standards”) are evidence‐based guidelines for psychosocial care in pediatric oncology. Care related to the three “Asking and Monitoring” Standards—Assessment of Psychosocial Needs, Assessment of Financial Needs, and Monitoring Neurocognitive Problems ...
Julia B. Tager, Natalie Koskela‐Staples, Emily M. Pariseau, Michele Scialla, Kimberly Buff, Lori Wiener, Victoria Sardi Brown, Anne E. Kazak, Kimberly S. Canter   +8 more
wiley   +1 more source

Design, Synthesis, and Biological Evaluation of Novel PARP-1 Inhibitors Based on a 1H-Thieno[3,4-d] Imidazole-4-Carboxamide Scaffold

Molecules, 2016
A series of poly(ADP-ribose)polymerase (PARP)-1 inhibitors containing a novel scaffold, the 1H-thieno[3,4-d]imidazole-4-carboxamide moiety, was designed and synthesized.
Lingxiao Wang, Feng Liu, Ning Jiang, Wenxia Zhou, Xinbo Zhou, Zhibing Zheng   +5 more
doaj   +1 more source

Safety and Effectiveness of a High‐Dose, Tailored Tissue Plasminogen Activator Therapy Protocol: A Joint Pediatric Hematology and Cardiac ICU Quality Improvement Initiative Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric thromboembolism is increasingly encountered in critical care. Systemic thrombolysis with tissue plasminogen activator (tPA) facilitates vessel or valve patency, yet pediatric‐specific protocols remain undefined, and safety concerns persist. Objective To evaluate the efficacy and safety of a tailored, prolonged systemic tPA
Eran Shostak, Oded Gilad, Yael Feinstein, Sigal Nakav, Ofer Schiller, Joanne Yacobovich   +5 more
wiley   +1 more source

Transformer-accelerated discovery of inhibitors targeting the RpsAΔ438 deletion in PZA-resistant tuberculosis

Journal of Cheminformatics
Tuberculosis is a major global public health problem caused by Mycobacterium tuberculosis. Pyrazinamide (PZA), a key first-line drug, is activated to pyrazinoic acid, which inhibits Mycobacterium tuberculosis by targeting ribosomal protein S1 (RpsA) and ...
Jiazhuo Xiao, Muhammad Shahab, Haoke Zhang, Zunnan Huang   +3 more
doaj   +1 more source

Ferroptosis and triple-negative breast cancer: Potential therapeutic targets

Frontiers in Oncology, 2022
PurposeTriple-negative breast cancer (TNBC) is an aggressive tumor with poor prognosis, it has higher recurrence and metastatic rates than other breast cancer subtypes.
Na Xu, Na Xu, Baohong Li, Yong Liu, Yong Liu, Cui Yang, Cui Yang, Siqi Tang, Siqi Tang, William C. Cho, Zunnan Huang, Zunnan Huang, Zunnan Huang   +12 more
doaj   +1 more source

Global Efforts to Reduce Paediatric Cancer Care Disparities in Radiotherapy: A Decade Change

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background We present an update on the status, needs and challenges faced by paediatric imaging and radiotherapy (RT) programmes globally after a previous survey conducted by the International Atomic Energy Agency (IAEA) 10 years prior. Methods We developed and distributed a 121‐question survey to radiation oncologists, medical physicists and ...
Raymond B. Mailhot Vega, Daniel J. Indelicato, Jeanette Parkes, Natia Esiashvili, Josué Hernández Benítez, Miriam Mikhail‐Lette, Olivera Cirajc Bjelac, Daniel Berger, Eva Ciurana, Yavuz Anacak, Lisbeth Cordero‐Mendez   +10 more
wiley   +1 more source

Proceedings of Formal Methods in Computer-Aided Design, FMCAD 2019 [PDF]

, 2019
Table of Contents: Boosting Verification Scalability via Structural Grouping and Semantic Partitioning of Properties / by Rohit Dureja, Jason Baumgartner, Alexander Ivrii, Robert Kanzelman and Kristin Yvonne Rozier (p.
Formal Methods in Computer Aided Design
core  

Experience With Performing Rheocarna Therapy via the Single‐Needle Method for Treatment of Chronic Limb‐Threatening Ischemia

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This study investigated the safety and efficacy of single‐needle Rheocarna therapy for chronic limb‐threatening ischemia (CLTI) with wounds. Methods Six patients with CLTI involving ulcers unresponsive to revascularization underwent single‐needle Rheocarna treatment.
Yasutaka Yamauchi, Rie Tanaka, Reona Kawahira, Shingo Nabeta, Kouhei Naoi, Kazuhito Kitajima, Akira Wada, Tomonari Takagi, Norihiko Ohura, Akira Miyamoto   +9 more
wiley   +1 more source

Proceedings of Formal Methods in Computer Aided Design, FMCAD 2018 [PDF]

, 2018
October 30 – November 2, 2018 in Austin, Texas, USATable of Contents: INVITED PAPERS -- Formal Verification of Deep Neural Networks / by Nina Narodytska (p. 1) -- Formal Verification of Unsatisfiability Results / by Marijn Heule (p.
Formal Methods in Computer Aided Design
core