Results 81 to 90 of about 12,983,542 (274)

Rethinking Computer-Aided Architectural Design (CAAD) – From Generative Algorithms and Architectural Intelligence to Environmental Design and Ambient Intelligence

, 2022
Computer-Aided Architectural Design (CAAD) finds its historical precedents in technological enthusiasm for generative algorithms and architectural intelligence.
Paul Sanders, Frid, Emma,, Emma Frid, Todor Stojanovski, Peters, Christopher,, Lefosse, Deborah,, Ivor Samuels, Samuels, Ivor,, Partanen, Jenni,, Stojanovski, Todor,, Chhatre, Kiran,, Kiran Chhatre, Jenni Partanen, Deborah Lefosse, Christopher Peters, Zhang, Hui,, Sanders, Paul,, Hui Zhang   +17 more
core   +1 more source

Assessment of SWI/SNF chromatin remodeling complex related genes as potential biomarkers and therapeutic targets in pan-cancer

Molecular Cancer
Recent research has uncovered a surprisingly high occurrence of aberrant expression and mutations in the genes that encode subunits of the SWI/SNF chromatin-remodeling complexes (SCRC).
Kai Zhuang, Lishan Wang, Chengyu Lu, Zhiping Liu, Dongli Yang, Hao Zhong, Jiami Zou, Aamir Fahira, Jiaojiao Wang, Zunnan Huang   +9 more
doaj   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Computer-aided molecular design : theory and applications /

, 1996
The computer-aided design of novel molecular systems has undoubtedly reached the stage of a mature discipline offering a broad range of tools available to virtually any chemist.
Weber, Jacques., Doucet, Jean-Pierre.
core  

Unveiling the impact of interferon genes on the immune microenvironment of triple-negative breast cancer: identification of therapeutic targets

Frontiers in Bioinformatics
ObjectiveTriple-negative breast cancer (TNBC), a classic subtype of breast cancer, is challenging to treat due to the lack of drug-targeting receptors.
Ying Liu, Ying Liu, Jiayi Cai, Aamir Fahira, Kai Zhuang, Jiaojiao Wang, Zhi Zhang, Lin Yan, Yong Liu, Yong Liu, Defang Ouyang, Zunnan Huang, Zunnan Huang, Zunnan Huang   +13 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Computer Aided Aroma Design. II. Quantitative structure-odour relationship [PDF]

, 2008
Computer Aided Aroma Design (CAAD) is likely to become a hot issue as the REACH EC document targets many aroma compounds to require substitution. The two crucial steps in CAMD are the generation of candidate molecules and the estimation of properties ...
A.-Hassan Meniai, Saci Nacef, Nacef, Saci, Vincent Gerbaud, Thierry Talou, Pascal Floquet, Korichi, Mourad, Talou, Thierry, Floquet, Pascal, Gerbaud, Vincent, Meniai, A.-Hassan, Mourad Korichi   +11 more
core   +1 more source

Therapeutic Potential of Antiviral Peptides against the NS2B/NS3 Protease of Zika Virus

ACS Omega, 2023
Md. Shahadat Hossain, Md. Tanjil Islam Shovon, Md. Rafid Hasan, Fuad Taufiqul Hakim, Mohammad Mehedi Hasan, Sadia Afrose Esha, Sabiha Tasnim, Md. Shahoriar Nazir, Fahmida Akhter, Md Ackas Ali, Mohammad A. Halim   +10 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Computer Aided Aroma Design. I. Molecular knowledge framework [PDF]

, 2008
Computer Aided Aroma Design (CAAD) is likely to become a hot issue as the REACH EC document targets many aroma compounds to require substitution. The two crucial steps in CAMD are the generation of candidate molecules and the estimation of properties ...
Nacef, Salif, Joulia, Xavier, Korichi, Mourad, Floquet, Pascal, Gerbaud, Vincent, Meniai, A.-Hassan   +5 more
core   +1 more source