Results 51 to 60 of about 805,019 (347)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Introduction to digital pathology and computer-aided pathology [PDF]

Journal of Pathology and Translational Medicine, 2020
Digital pathology (DP) is no longer an unfamiliar term for pathologists, but it is still difficult for many pathologists to understand the engineering and mathematics concepts involved in DP. Computer-aided pathology (CAP) aids pathologists in diagnosis.
Soojeong Nam, Yosep Chong, Chan Kwon Jung, Tae-Yeong Kwak, Ji Youl Lee, Jihwan Park, Mi Jung Rho, Heounjeong Go   +7 more
doaj   +1 more source

Computer-aided re-engineering of nonribosomal peptide and polyketide biosynthetic assembly lines.

Natural product reports (Print), 2019
Covering: 2014 to 2019Nonribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs) have been the subject of engineering efforts for multiple decades.
Mohammad Alanjary, Carolina Cano-Prieto, H. Gross, Marnix M Medema   +3 more
semanticscholar   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Cameo: A Python Library for Computer Aided Metabolic Engineering and Optimization of Cell Factories

bioRxiv, 2017
Computational systems biology methods enable rational design of cell factories on a genomescale and thus accelerate the engineering of cells for the production of valuable chemicals and proteins.
João G. R. Cardoso, Kristian Jensen, Christian Lieven, A. L. Hansen, Svetlana Y. Galkina, M. Beber, E. Özdemir, Markus J. Herrgård, Henning Redestig, Nikolaus Sonnenschein   +9 more
semanticscholar   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Spatiotemporal Trajectories of Pedestrian Mobility at the Train Station: evidence of 24 million trajectories

Scientific Data
Understanding pedestrian movement remains crucial for designing efficient and safe transportation structures such as terminals, stations, or airports. The significance of conducting a granular analysis in pedestrian mobility dynamics research is evident ...
Tomáš Apeltauer, Ondřej Uhlík, Jiří Apeltauer, Vojtěch Juřík   +3 more
doaj   +1 more source

Analyzing positional accuracy and structural efficiency in additive manufacturing systems with moving elements

Results in Engineering
Simulation is a useful tool for designing and analyzing the characteristics of a system being investigated. In this investigation, modal simulation and harmonic response analysis are performed to predict the dynamic characteristics of an additive ...
Tzu-Chi Chan, Sai Vijay Medarametla, Ratnakar behera   +2 more
doaj   +1 more source

Computer-aided reverse engineering system in the design and production of orthotic insole shoes for patients with diabetes

, 2018
Design and manufacturing strategies for custom orthotic insole shoes for patients with diabetes are presented in this paper. The computer-aided reverse engineering system (CARESystem) was applied for minimizing file errors generated by scanning a patient’
P. W. Anggoro, M. Tauviqirrahman, J. Jamari, A. P. Bayuseno, B. Bawono, M. Avelina   +5 more
semanticscholar   +1 more source