Results 91 to 100 of about 145,245 (295)

Transformative mappings: the cartographers house in the ecologists garden Reporting on a work-in-progress

open access: yesLandscape Review, 2001
My thesis, entitled 'Transformative Mappings: the cartographer's house in the ecologist's garden', part design and part text, is concerned with contemporary design theory.
Ian Weir
doaj  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

An intelligent computer-aided design system incorporating considerations for aesthetics and the environment [PDF]

open access: yes, 2007
Amidst intense competition, manufacturers are constantly striving to improve their competence with others. In this respect, aesthetics of the product has become one of the prime factors in capturing market share.
Harunur Rashid, Abu Raihan Md.
core  

The Sensitivity of State Differential Game Vessel Traffic Model

open access: yesPolish Maritime Research, 2016
The paper presents the application of the theory of deterministic sensitivity control systems for sensitivity analysis implemented to game control systems of moving objects, such as ships, airplanes and cars.
Lisowski Józef
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

THE APPLICATION OF GENERAL THEORY OF ROOT TRAJECTORIES METHODS IN RESEARCH OF MULTI-CHANNEL CONTROL SYSTEM WITH CROSS-CONNECTIONS

open access: yesInformatika, 2017
Computer aided research method on the basis of general theory of root trajectories is considered in the frame of study of multi-channel control systems with varying parameters included as cofactors with arbitrary exponents in coefficients of the ...
V. V. Tkachenko
doaj  

Encoding Theory of Mind in Character Design for Pedagogical Interactive Narrative

open access: yesAdvances in Human-Computer Interaction, 2014
Computer aided interactive narrative allows people to participate actively in a dynamically unfolding story, by playing a character or by exerting directorial control.
Mei Si, Stacy C. Marsella
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

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