Results 101 to 110 of about 145,245 (295)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
THE DESIGN OF PROFILE CURVE AND MOTION SIMULATION OF PROFILING MOULD BASED ON PRO/E SOFTWARE
Jixie qiangdu, 2015 By the common method of profiling mould the design curve mode contour mapping method and calculation method. Calculation process is cumbersome,require computer-aided programming is complete,and the traditional mapping method also has the error,the ...
LIN Sheng
doaj
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
A Perspective on Computer Aided Design after Four Decades
, 2008 We offer a summary view of competing theories that have guided and inspired the development of computer aided design over the past forty years with attention to how they support design processes. We identify eight distinct approaches to design.
E. Mark, M. Gross, G. Goldschmidt
core
Preface [en 12th International Conference on Computer Aided Systems Theory, EUROCAST 2009]
, 2011 VIV0 ...
Pichler, Franz +2 more
core +1 more source
A method for estimating the contact area of a dual-mobility total hip prosthesis
AIP AdvancesThe term “contact area” refers to the total surface area of two entities in direct physical touch. When discussing an artificial hip joint, “contact area” refers to the surface area of contact between the components of the artificial hip joint (ball and ...
Taufiq Hidayat +7 more
doaj +1 more source
Research status and prospects of free-form surface modeling theory for CAD, CAE and CAM
Xibei Gongye Daxue XuebaoFree-form surface modelling theory is the study of how to describe and construct free-form surfaces in the computer, and how to interactively display, modify and control them.
HAN Feiyan +5 more
doaj +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa +2 more
wiley +1 more source