Results 111 to 120 of about 392,476 (333)
Informatika, 2017 Computer aided research method on the basis of general theory of root trajectories is considered in the frame of study of multi-channel control systems with varying parameters included as cofactors with arbitrary exponents in coefficients of the ...
V. V. Tkachenko
doaj
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
Encoding Theory of Mind in Character Design for Pedagogical Interactive Narrative
Advances in Human-Computer Interaction, 2014 Computer aided interactive narrative allows people to participate actively in a dynamically unfolding story, by playing a character or by exerting directorial control.
Mei Si, Stacy C. Marsella
doaj +1 more source
A Study on the Application of Computer-Aided Dual-Coding Theory in English Vocabulary Teaching [PDF]
, 2022 Li Luo
openalex +1 more source
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
THE DESIGN OF PROFILE CURVE AND MOTION SIMULATION OF PROFILING MOULD BASED ON PRO/E SOFTWARE
Jixie qiangdu, 2015 By the common method of profiling mould the design curve mode contour mapping method and calculation method. Calculation process is cumbersome,require computer-aided programming is complete,and the traditional mapping method also has the error,the ...
LIN Sheng
doaj
Theoretical, Measured and Subjective Responsibility in Aided Decision Making
, 2020 When humans interact with intelligent systems, their causal responsibility for outcomes becomes equivocal. We analyze the descriptive abilities of a newly developed responsibility quantification model (ResQu) to predict actual human responsibility and ...
Douer, Nir, Meyer, Joachim
core
FEBS Open Bio, EarlyView.NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source