Results 61 to 70 of about 392,476 (333)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Study on Man-machine Design of Armoured Vehicles Operation Space

MATEC Web of Conferences, 2018
This paper proposes an improved armoured vehicle control room based on ergonomic theory and computer-aided design technology to create efficiency by improving panel layout and seat design.
Hemin Du, Ting Wang
doaj   +1 more source

Theorema: Towards computer-aided mathematical theory exploration

Journal of Applied Logic, 2006
AbstractTheorema is a project that aims at supporting the entire process of mathematical theory exploration within one coherent logic and software system. This survey paper illustrates the style of Theorema-supported mathematical theory exploration by a case study (the automated synthesis of an algorithm for the construction of Gröbner Bases) and gives
Buchberger, Bruno, Crǎciun, Adrian, Jebelean, Tudor, Kovács, Laura, Kutsia, Temur, Nakagawa, Koji, Piroi, Florina, Popov, Nikolaj, Robu, Judit, Rosenkranz, Markus, Windsteiger, Wolfgang   +10 more
openaire   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Square Root of a Multivector of Clifford Algebras in 3D: A Game with Signs

Mathematics
An algorithm is presented to extract the square root from a multivector (MV) in real Clifford algebras Clp,q, where n=p+q≤3, in radicals. It is shown that in Cl3,0, Cl1,2, and Cl0,3 algebras, there are up to four isolated square roots in a case of the ...
Arturas Acus, Adolfas Dargys
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Multidimensional Digital Signal Estimation Using Kalman’s Theory for Computer-Aided Applications [PDF]

, 2004
In this paper, we analyze the Multidimensional Kalman Algorithm to estimate a signal corrupted by white Gaussian noise. Because the theory provide a good solution to the problem with a large number of signals, we developed an algorithm for three ...
Andrade-Lucio, José A., Ibarra-Manzano, Óscar G., Villalón-Turrubiates, Iván E.   +2 more
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

SEARCHING SHEAR FORCES FLOWS FOR AN ARBITRARY CROSS-SECTION OF A THIN-WALLED BAR: DEVELOPMENT OF NUMERICAL ALGORITHM BASED ON THE GRAPH THEORY

International Journal for Computational Civil and Structural Engineering, 2019
Searching problem of shear stresses on outside longitudinal edges of an arbitrary cross-section (including open-closed multi-contour cross-sections) of a thin-walled bar subjected to the general load case has been considered in the paper.
Vitalina Yurchenko
doaj   +1 more source