Results 121 to 130 of about 576,672 (286)
Computer-assisted design of organic synthesis [PDF]
The computer programs to design synthetic pathways of organic compounds have been utilized throughout the world since the first system was reported by Corey in 1969, and the LHASA was reported in1972 to become the predominant system.
Kaminaka, H.
core +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Developing Computer-Assisted Tutorial Instructional Program for Teaching Grammar in Higher Education [PDF]
, 2015 The aims of this research were to: (1) gain information on the existing condition of learning media which are used by lecturers to teach grammar, (2) develop the proper media which is suitable for the students' need and appropriate to teach grammar, and (
Asib, A. (Abdul) +2 more
core
Effective algorithm of analysis of integrability via the Ziglin's method
, 2014 In this paper we continue the description of the possibilities to use numerical simulations for mathematically rigorous computer assisted analysis of integrability of dynamical systems.
AJ Maciejewski +3 more
core +3 more sources
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Multistep Networks for Deformable Multimodal Medical Image Registration
IEEE AccessWe proposed neural networks for deformable multimodal medical image registration that use multiple steps and varying resolutions. The networks were trained jointly in an unsupervised manner with Mutual Information and Gradient L2 loss.
Anika Strittmatter, Frank G. Zollner
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
A Supplemental computer-assisted intervention to prevent early reading difficulties in spanish learners: a randomised controlled trial [PDF]
, 2016 Difficulties implementing effective instruction for at-risk students arise from two challenges: evidence-based knowledge transfer and lack of economic resources. Computer-assisted programs can offer a suitable solution, providing quality instruction with
Bordoy Castro, Soraya +4 more
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Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source