Results 81 to 90 of about 10,773,976 (296)

Evaluation of the usefulness of a computer‐based learning program to support student learning in pharmacology [PDF]

, 1999
This study aims to evaluate the effectiveness of a computer‐based teaching program in supporting and enhancing traditional teaching methods. The program covers the pharmacology of inflammation and has been evaluated with a group of second‐year medical ...
A. D. Williams, Brain, S., S. Brain, Dewhurst, D. G., Williams, A. D., D. G. Dewhurst   +5 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Book Review: Computer-Assisted Language Learning in the Global South: Exploring Challenges and Opportunities for Students and Teachers

The EUROCALL Review
Computer-Assisted Language Learning in the Global South: Exploring Challenges and Opportunities for Students and Teachers Edited by Lee McCallum and Dara Tafazoli Published in 2024 by Taylor & Francis Pages: 230 DOI: https://doi.org/10.4324 ...
Harsha Dulari Wijesekera
doaj   +1 more source

The Visual Elements of Computer-based Language Assessment: Aspects and Effects

Studies in Applied Linguistics & TESOL, 2012
The advent of computers and computer assisted technologies has certainly influenced many aspects of our personal and professional lives. The field of second language education is no exception, where such technologies first exerted their influence on ...
Sarab Al-Ani
doaj   +1 more source

Comparison of the cost‐effectiveness of a computer‐assisted learning program with a tutored demonstration to teach intestinal motility to medical students [PDF]

, 1995
Computer‐based simulations of undergraduate experiments in pharmacology and physiology may offer a cost‐effective alternative to the traditional live laboratory for some students, for whom laboratory skills are less important.
D. G. Dwehurst, Dewhurst, D. G., H. L. Leathard, Leathard, H. L.   +3 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

The Visual Elements of Computer-based Language Assessment: Aspects and Effects

Working Papers in Applied Linguistics and TESOL, 2015
The advent of computers and computer assisted technologies has certainly influenced many aspects of our personal and professional lives. The field of second language education is no exception, where such technologies first exerted their influence on ...
Sarab Al-Ani
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Effective Instructor Feedback: Perceptions of Online Graduate Students

Journal of Educators Online, 2009
This descriptive study explored online graduate students' perceptions of effective instructor feedback. The objectives of the study were to determine the students’ perceptions of the content of effective instructor feedback (“what should be included in ...
Beverley Getzlaf, Beth Perry, Greg Toffner, Kimberley Lamarche, Margaret Edwards   +4 more
doaj   +1 more source