Results 71 to 80 of about 465,123 (372)

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Contextual Teaching with Computer-Assisted Instruction [PDF]

, 2010
Computer technology has made substantial contributions to education and educators are now confronted with determining how to best incorporate it as a teaching tool. Educators have also long struggled with how to make what is learned in school more useful
Leach, Lynn, Putnam, A R
core   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

The impact of computer-assisted mathematics instruction for secondary students with learning disabilities [PDF]

, 2002
The purposes of this explorative study were to (a) compare results of the mathematics achievement of a group of secondary students with learning disabilities with and without computer-assisted instruction (n = 10) ; and (b) examine student satisfaction ...
Celentano, Shirley A.
core   +1 more source

Students and Graduates Learn Library Educational Content from Interactive Multimedia Tutorials. A review of: Markey, Karen, Annie Armstrong, Sandy De Groote, Michael Fosmire, Laura Fuderer, Kelly Garrett, Helen Georgas, Linda Sharp, Cheri Smith, Michael Spaly, and JoniE. Warner. “Testing the Effectiveness of Interactive Multimedia for Library‐User Education.” portal: Libraries & the Academy 5.4 (Oct. 2005): 527‐54

Evidence Based Library and Information Practice, 2006
Objective –To demonstrate the effectiveness of interactive multimedia tutorials in delivering library educational content, and to evaluate librarian experiences of developing multimedia tutorials, both aspart of the LUMENS (Drabenstott) project.Design ...
David Herron, Lotta Haglund
doaj  

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

PENGEMBANGAN MEDIA COMPUTER ASSISTED INSTRUCTION DALAM MATA PELAJARAN IPA TEMA 5 MATERI POKOK PERTUMBUHAN DAN BAGIAN-BAGIAN TANAMAN UNTUK SISWA KELAS VI TUNARUNGU DI SLB TUNAS MULYA SURABAYA [PDF]

, 2018
Abstrak Tujuan penelitian ini adalah sebagai (1) Menguji kelayakan media Computer Assisted Instruction Materi Pokok Pertumbuhan Dan Bagian-Bagian Tanaman Untuk Siswa Kelas VI Tunarungu Di SLB Tunas Mulya Surabaya (2) Menguji keefektifitasan media ...
, SULISTIOWATI, SARI, MAYANG
core   +1 more source

PENGEMBANGAN MEDIA COMPUTER ASSISTED INSTRUCTION MATA PELAJARAN DASAR DESAIN GRAFIS UNTUK KELAS X JURUSAN MULTIMEDIA DI SMK MUHAMMADIYAH 2 SURABAYA [PDF]

, 2020
Abstrak Tujuan penelitian pengembangan ini adalah (1) untuk mengembangkan media CAI (Computer Assisted Instruction) yang layak pada Materi Wujud Tekstur Mata Pelajaran Dasar Desain Grafis di SMK Muhammadiyah 2 Surabaya.
EKA YULIANTI, HESTI
core   +1 more source

THE EFFECT OF COMPUTER MEDIATED CONFERENCING AND COMPUTER ASSISTED INSTRUCTION ON STUDENT LEARNING OUTCOMES

Online Learning, 2019
The trend toward increased technology in traditional higher education classrooms has been met with both optimism and criticism. One of the major criticisms of technology in the college classroom is that it does little, if anything, to improve student ...
Darrell L. Cain, Paul E. Pitre
doaj   +1 more source