Results 81 to 90 of about 3,974,204 (263)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Pengaruh Computer-Assisted Instruction dan Pengetahuan Awal terhadap Hasil Belajar Teknik Pemesinan CNC

Jurnal Teknologi Pendidikan, 2017
The study examined the effect of computer-assisted instruction and prior knowledge on SMK N 1 Bekasi students’ CNC machine learning outcomes, Eleventh grade. This study adopted a treatment by level 2 x 2 design.
Hijrah Syahputra
doaj   +1 more source

The Study of Effect of Multimedia Computer-Assisted Instruction on the Teaching of Integer Arithmetic Operations

, 2009
[[abstract]]Abstract The study aims to analyze the effect of multimedia computer-assisted instruction on the teaching of integer arithmetic operations in elementary school.
Juang Yu-Shiuan
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Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Relative Effectiveness of Computer-Assisted Instructional Strategy on Students’ Learning Outcomes in Mathematics

West African Journal of Open and Flexible Learning
This study investigated the relative effectiveness of computer-assisted instructional strategy on senior secondary school students’ learning outcomes in mathematics.
I.O Salawu , O.N Oyarinde
doaj  

El análisis didáctico-tecnológico del proceso de enseñanza-aprendizaje de la Matemática/ The didactic-technological analysis of the teaching-learning process of Mathematics

Transformación, 2018
The teaching-learning process of Mathematics is currently undergoing constant changes resulting from the achievements of Information and Communication Technologies, that UNESCO has recognized a priority of the agenda for the Education 2030.
Carmen Fortuna González Trujillo, Nancy Montes de Oca Recio, Sonia Guerrero Lambert   +2 more
doaj  

Computer-assisted instruction versus inquiry-based learning: The importance of working memory capacity. [PDF]

PLoS One, 2021
Chevalère J, Cazenave L, Berthon M, Martinez R, Mazenod V, Borion MC, Pailler D, Rocher N, Cadet R, Lenne C, Maïonchi-Pino N, Huguet P.   +11 more
europepmc   +1 more source

Computer Assisted Instruction And Academic Achievement In Counselor Education

, 2005
The purpose of this study was to examine the effects of computer assisted instruction on academic achievement. The participants were 138 graduate students enrolled in a beginning level counselor education course (12 men and 126 women with ages ranging ...
Karper, Christine Marie, Robinson, E. H., Casado, Montse   +2 more
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