Results 31 to 40 of about 2,980,350 (288)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Manuscript Investigation in the Sinai II Project
Digital Presentation and Preservation of Cultural and Scientific Heritage, 2014 This work is concerned with the analysis of historical manuscripts. The manuscripts investigated are partially in a bad condition, due to their age, bad storage conditions etc.
Fabian Hollaus +4 more
doaj +1 more source
Automated image computing reshapes computational neuroscience [PDF]
BMC Bioinformatics, 2013 We briefly identify several critical issues in current computational neuroscience, and present our opinions on potential solutions based on bioimage informatics, especially automated image computing.
Hanchuan Peng +2 more
openaire +3 more sources
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Three Point Lighting Design Automation for Computer Graphics
, 2012 [[abstract]]In this paper, we will discuss the possibility of automating the process of lighting setup in computer graphics. We focus on a well-established technique known as “three-point lighting”. We devised a process of lighting setup automation based
Su Ian Eugene Lei;Chun-Fa Chang
core +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Цифровая трансформацияThe main methodological problems and strategic goals of work on creating the theory and technology of intelligent computer systems of a new generation are considered.
V. V. Golenkov +2 more
doaj +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
Cancer Imaging, 2023 Background Pancreatic ductal carcinoma patients have a really poor prognosis given its difficult early detection and the lack of early symptoms. Digital pathology is routinely used by pathologists to diagnose the disease. However, visually inspecting the
Francisco Carrillo-Perez +4 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source