Results 41 to 50 of about 97,408 (313)
A mechanism for activating end-user learning and participation in office automation [PDF]
, 1990 This thesis is about 'User Involvement', a theme that is becoming the core of a growing body of research in the area of systems development and implementation.
Kaddah, Mona Maamoun, Kaddah, M.M
core
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Attention and automation: New perspectives on mental underload and performance
, 2002 There is considerable evidence in the ergonomics literature that automation can significantly reduce operator mental workload. Furthermore, reducing mental workload is not necessarily a good thing, particularly in cases where the level is already ...
Young, Mark S. +3 more
core +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
DEVELOPMENT OF COMPUTER AIDED DESIGN OF CHAIN COUPLING
International Journal of Advanced Studies, 2015 The present paper describes the development stages of computer-aided design of chain couplings. The first stage is the automation of traditional design techniques (intermediate automation).
Sergey Aleksandrovich Sergeev
doaj
Summary of researches being performed in the Institute of Mathematics and Computer Science on computer science and information technologies [PDF]
Computer Science Journal of Moldova, 2008 Evolution of the informatization notion (which assumes automation of majority of human activities applying computers, computer networks, information technologies) towards the notion of {\it Global Information Society} (GIS) challenges the determination ...
Artiom Alhazov +9 more
doaj
Automatic Detection of Olive Tree Canopies for Groves with Thick Plant Cover on the Ground
Sensors, 2022 Marking the tree canopies is an unavoidable step in any study working with high-resolution aerial images taken by a UAV in any fruit tree crop, such as olive trees, as the extraction of pixel features from these canopies is the first step to build the ...
Sergio Illana Rico +3 more
doaj +1 more source
Translation as human-computer interaction [PDF]
, 2012 This paper seeks to characterise translation as a form of human-computer interaction. The evolution of translator-computer interaction is explored and the challenges and benefits are enunciated.
O'Brien, Sharon, O\u27Brien, Sharon
core +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source