Results 41 to 50 of about 65,168 (264)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

A Criteria Transformation Approach to Pattern Matching based on Non-Linear Parameter Optimization

Journal of Intelligent Systems, 2015
This paper presents a concept for pattern matching based on a parameter optimization system for approximative numerical calculation of some parameter combination under soft and hard constraints. The concept uses a non-linear parameter optimization method
John Christian, Tutsch Dietmar, Lepich Thomas, Beitz Bernard, Möller Reinhard   +4 more
doaj   +1 more source

Image Processing Algorithms Used in Robotics Applications

Communications, 2000
The paper presents the results obtained in implementing image-processing algorithms (edge detection, contour closing, skeletonizing). Several classical as well as two original algorithms are presented, together with sample images from the implementation.
Gheorghe Lazea, Alin Muresan, Emil Lupu
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Development of the computer-aided process planning (CAPP) system for polymer injection molds manufacturing

Metalurgija, 2011
Beginning of production and selling of polymer products largely depends on mold manufacturing. The costs of mold manufacturing have significant share in the final price of a product.
J. Tepić, V. Todić, D. Lukić, M. Milošević, S. Borojević   +4 more
doaj  

Automatization of Measurements of Photoelectric Parameters of High Impedance Semiconductor Films

Фізика і хімія твердого тіла, 2019
A method for measuring the electrical conductivity and photoconductivity of semiconductor films with high electrical resistance is described. An electric circuit is presented and a computer program is developed.
B. S. Dzundza, V. V. Prokopiv, T. M. Mazur, L. D. Yurchyshyn   +3 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Intelligent Energy Management of Hybrid Microgrid Using Deep Learning–Based Optimal Predictive Controller

Journal of Electrical and Computer Engineering
The increasing integration of renewable energy sources into hybrid microgrids has significantly improved the sustainability of power systems. However, the intermittent nature of solar and wind generation makes real-time energy management a major ...
Vinny Junior Foba Kakeu, Samuel Eke, Felix Ghislain Yem Souhe, Camille Franklin Mbey, Alexandre Teplaira Boum   +4 more
doaj   +1 more source

Application of thermal sterilization regimes simulation for improvement of canned foods quality factors [PDF]

Vestnik MGTU, 2015
Results of comparison of optimization methods of thermal sterilization temperature-time regimes have been described. It has been shown that due to simulation the final canned foods’ quality factors are significantly improved, sterilization process time ...
Stolyanov A.V., Kaychenov A.V. , Maslov A.A., Vlasov A.V. , Ereshchenko V.V.   +4 more
doaj