Results 61 to 70 of about 97,408 (313)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Metalurgija, 2011 Beginning of production and selling of polymer products largely depends on mold manufacturing. The costs of mold manufacturing have significant share in the final price of a product.
J. Tepić +4 more
doaj
Application of thermal sterilization regimes simulation for improvement of canned foods quality factors [PDF]
Vestnik MGTU, 2015 Results of comparison of optimization methods of thermal sterilization temperature-time regimes have been described. It has been shown that due to simulation the final canned foods’ quality factors are significantly improved, sterilization process time ...
Stolyanov A.V. +4 more
doaj
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Journal of Electrical and Computer EngineeringThe reliability of smart transmission systems critically depends on the rapid and accurate detection and localization of faults. However, existing approaches face inherent limitations; thus, traveling-wave (TW) methods offer high localization accuracy ...
Felix Ghislain Yem Souhe +4 more
doaj +1 more source
InformationRobots and smart technologies are becoming part of everyday life and private households. While this automation of mundane tasks typically creates pragmatic benefits (e.g., efficiency, accuracy, time savings), it may also come with psychological losses ...
Sarah Diefenbach +3 more
doaj +1 more source
Revitalization of College Libraries with Computer Assistance [PDF]
, 1995 Availability and utilization in teaching learning process; of up-to-date information on topics dealt in colleges is essential to maintain the quality and relevance of college education. The study observes that presently the college libraries in India are
Raman Nair, R.
core
Computer simulation for undergraduate engineering education
, 2009 Computer simulation has been popularly used in education for a few decades while its effects on engineering curriculum do not achieve so much success as on other curriculum.
Xia Hong +9 more
core +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source