Results 31 to 40 of about 1,158,587 (297)
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
A conceptual architecture for interactive educational multimedia [PDF]
, 2006 Learning is more than knowledge acquisition; it often involves the active participation of the learner in a variety of knowledge- and skills-based learning and training activities.
Pahl, Claus
core +4 more sources
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
A Cerebellar Neuroprosthetic System: Computational Architecture and in vivo Test [PDF]
Frontiers in Bioengineering and Biotechnology, 2014 Emulating the input-output functions performed by a brain structure opens the possibility for developing neuroprosthetic systems that replace damaged neuronal circuits. Here, we demonstrate the feasibility of this approach by replacing the cerebellar circuit responsible for the acquisition and extinction of motor memories.
Herreros, Ivan +7 more
openaire +2 more sources
Supporting Constructive Learning with a Feedback Planner [PDF]
, 2000 A promising approach to constructing more effective computer tutors is implementing tutorial strategies that extend over multiple turns. This means that computer tutors must deal with (1) failure, (2) interruptions, (3) the need to revise their tactics ...
Core, Mark G. +2 more
core +2 more sources
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
BTI Aging Influence Analysis and Mitigation in Flash ADCs
ChipsBias Temperature Instability (BTI)-induced aging of transistors is a serious concern in modern electronic circuits, yet its effects on the operation of mixed-signal circuits have not been extensively studied.
Konstantina Mylona +2 more
doaj +1 more source
Large computer systems and new architectures addendum [PDF]
Computer Physics Communications, 1982 Abstract This addendum brings the paper referenced up-to-date as of January 1981. The new market situation in the area of super computers is reviewed and the only really new machine, the CDC CYBER 205, is described. The CRAY-1S series is briefly described and the FPS-164 is mentioned. The fact that Burroughs discontinued the BSP project is mentioned.
openaire +1 more source
Multi-layer Architecture For Storing Visual Data Based on WCF and Microsoft SQL Server Database
, 2015 In this paper we present a novel architecture for storing visual data. Effective storing, browsing and searching collections of images is one of the most important challenges of computer science.
A. Biniaz +22 more
core +1 more source